iPTMnet Report for Q99814 (EPAS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99814 / EPAS1_HUMAN
Protein Name Endothelial PAS domain-containing protein 1
Gene Name Name: EPAS1
Synonyms:BHLHE73,HIF2A,MOP2,PASD2;
Organism Homo sapiens (Human)

PRO ID PR:Q99814
DAG View
PRO Name endothelial PAS domain-containing protein 1 (human)
Definition An endothelial PAS domain-containing protein 1 that is encoded in the genome of human.
Short Label hEPAS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99814 (EPAS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
T324 Phosphorylation Q15139 (PRKD1) , O15530 (PDPK1) HPRD   PhosphoSitePlus   RLIMS-P 17024177
S383 Phosphorylation PhosphoSitePlus
K385 Acetylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K394 Sumoylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
K685 Acetylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
K741 Acetylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 L12 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
K291 N291 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T324 M324 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S383 C383 Biomuta DOID:4159 / skin cancer [ cosmic ]
K392 N392 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K497 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T528 I528 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K595 R595 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S672 Y672 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S795 N795 Biomuta DOID:363 / uterine cancer [ icgc ]