iPTMnet Report Q99759 MAP3K3

Protein Information

UniProt AC / UniProt ID	Q99759 / M3K3_HUMAN
Protein Name	Mitogen-activated protein kinase kinase kinase 3
Gene Name	Name: MAP3K3 Synonyms:MAPKKK3,MEKK3;
Organism	Homo sapiens (Human)

PRO ID	PR:Q99759 DAG View
PRO Name	mitogen-activated protein kinase kinase kinase 3 (human)
Definition	A mitogen-activated protein kinase kinase kinase 3 that is encoded in the genome of human.
Short Label	hMAP3K3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q99759 (MAP3K3) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K102	Ubiquitination		score1	PhosphoSitePlus
S130	Phosphorylation		score1	PhosphoSitePlus
S131	Phosphorylation		score1	PhosphoSitePlus
S145	Phosphorylation		score1	PhosphoSitePlus
S147	Phosphorylation		score1	PhosphoSitePlus
Y155	Phosphorylation		score1	PhosphoSitePlus
S162	Phosphorylation		score1	PhosphoSitePlus
S166	Phosphorylation	O00141 (SGK1)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	12392720, 12761204, 23186163, ...18220336
S168	Phosphorylation		score1	PhosphoSitePlus
S169	Phosphorylation		score1	PhosphoSitePlus
S175	Phosphorylation		score1	PhosphoSitePlus
S176	Phosphorylation		score1	PhosphoSitePlus
S194	Phosphorylation		score1	PhosphoSitePlus
S234	Phosphorylation		score1	PhosphoSitePlus
S237	Phosphorylation		score1	PhosphoSitePlus
S250	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 23186163, 19369195
T263	Phosphorylation		score1	PhosphoSitePlus
Y266	Phosphorylation		score1	PhosphoSitePlus
T274	Phosphorylation		score1	PhosphoSitePlus
Y275	Phosphorylation		score1	PhosphoSitePlus
Y288	Phosphorylation		score1	PhosphoSitePlus
S289	Phosphorylation		score1	PhosphoSitePlus
T294	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	18308725
S312	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S314	Phosphorylation		score1	PhosphoSitePlus
S316	Phosphorylation		score1	PhosphoSitePlus
T317	Phosphorylation		score1	PhosphoSitePlus
S337	Phosphorylation	O00141 (SGK1)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18691976, 23186163, 19369195, ...12392720, 12761204, 19690332, 12761205
S340	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 23186163, 19690332, ...19369195
S345	Phosphorylation		score1	PhosphoSitePlus
S355	Phosphorylation		score1	PhosphoSitePlus
S357	Phosphorylation		score1	PhosphoSitePlus
K366	Ubiquitination		score1	PhosphoSitePlus
K391	Ubiquitination		score1	PhosphoSitePlus
K404	Ubiquitination		score1	PhosphoSitePlus
K417	Ubiquitination		score1	PhosphoSitePlus
K456	Ubiquitination		score1	PhosphoSitePlus
S464	Phosphorylation		score1	PhosphoSitePlus
K491	Ubiquitination		score1	PhosphoSitePlus
K504	Ubiquitination		score1	PhosphoSitePlus
K512	Ubiquitination		score1	PhosphoSitePlus
T516	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	20068038
S520	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	20068038
S526	Phosphorylation	Q99759 (MAP3K3)	score4	PhosphoSitePlus RLIMS-P Signor	33571521, 16407301
T528	Phosphorylation		score1	PhosphoSitePlus
T530	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S130	Phosphorylation		score0	HPRD	18691976
S131	Phosphorylation		score0	HPRD	18691976
S145	Phosphorylation		score0	HPRD	18691976
S166	Phosphorylation	P17612 (PRKACA)	score2	HPRD	19651622, 18691976, 12392720
S168	Phosphorylation		score0	HPRD	18691976
S175	Phosphorylation		score0	HPRD	18691976, 20058876
S176	Phosphorylation		score0	HPRD	20058876
S234	Phosphorylation		score0	HPRD	18691976
S237	Phosphorylation		score0	HPRD	18691976
S250	Phosphorylation		score0	HPRD	18691976
Y288	Phosphorylation		score0	HPRD	17924679
S289	Phosphorylation		score0	HPRD	17924679
T294	Phosphorylation		score0	HPRD	17924679
S314	Phosphorylation		score0	HPRD	18691976
S337	Phosphorylation	P17612 (PRKACA)	score2	HPRD	18691976, 12392720
S340	Phosphorylation		score0	HPRD	19413330, 18691976
T353	Phosphorylation		score0	HPRD	18691976
S355	Phosphorylation		score0	HPRD	18691976
S526	Phosphorylation	Q99759 (MAP3K3)	score1	HPRD	16407301

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S55	Phosphorylation		score1	PhosphoSitePlus
T57	Phosphorylation		score1	PhosphoSitePlus
S161	Phosphorylation		score0	HPRD	18691976
S162	Phosphorylation		score0	HPRD	18691976
S176	Phosphorylation		score0	HPRD	18691976
S197	Phosphorylation	P17612 (PRKACA)	score2	HPRD	19651622, 18691976, 12392720
S199	Phosphorylation		score0	HPRD	18691976
S206	Phosphorylation		score0	HPRD	18691976, 20058876
S207	Phosphorylation		score0	HPRD	20058876
S265	Phosphorylation		score0	HPRD	18691976
S268	Phosphorylation		score0	HPRD	18691976
S281	Phosphorylation		score0	HPRD	18691976
Y319	Phosphorylation		score0	HPRD	17924679
S320	Phosphorylation		score0	HPRD	17924679
T325	Phosphorylation		score0	HPRD	17924679
S345	Phosphorylation		score0	HPRD	18691976
S368	Phosphorylation	P17612 (PRKACA)	score2	HPRD	18691976, 12392720
S371	Phosphorylation		score0	HPRD	19413330, 18691976
T384	Phosphorylation		score0	HPRD	18691976
S386	Phosphorylation		score0	HPRD	18691976
S557	Phosphorylation	Q99759 (MAP3K3)	score1	HPRD	16407301

Q99759 (MAP3K3) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P46734 (MAP2K3)	S218	score1	Signor	9162092
P53805 (RCAN1)	S163	score2	PhosphoSitePlus	16126726
P53805 (RCAN1)	S167	score4	PhosphoSitePlus Signor	16126726, 12809556
Q99759-1 (MAP3K3)	S526	score2	HPRD Signor	16407301
Q99759-2 (MAP3K3)	S557	score1	HPRD	16407301

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S130	F130	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S161	F161	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S162	G162	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S166	A166	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S166	P166	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S168	G168	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S168	T168	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S175	N175	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S197	P197	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S197	A197	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S199	T199	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S199	G199	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S206	N206	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S234	*	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
T263	S263	Biomuta	DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S265	*	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
Y266	C266	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K404	N404	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S520	L520	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S526	Y526	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S557	Y557	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q99759 (MAP3K3)

Protein Information

Interactive Sequence View

Q99759 (MAP3K3) as Substrate

Q99759 (MAP3K3) as PTM Enzyme

PTM sites affected in variants