Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99759 / M3K3_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 3
Gene Name Name: MAP3K3
Synonyms:MAPKKK3,MEKK3;
Organism Homo sapiens (Human)

PRO ID PR:Q99759
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 3 (human)
Definition A mitogen-activated protein kinase kinase kinase 3 that is encoded in the genome of human.
Short Label hMAP3K3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99759 (MAP3K3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K102 Ubiquitination PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S166 Phosphorylation O00141 (SGK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12392720, 12761204, 23186163, ...18220336
S168 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
T263 Phosphorylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus   RLIMS-P 18308725
S312 Phosphorylation PhosphoSitePlus   UniProt 23186163
S314 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
S337 Phosphorylation O00141 (SGK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 23186163, 18691976, ...12392720, 12761204, 19690332, 12761205
S340 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19690332, ...19369195
S345 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus   RLIMS-P 20068038
S520 Phosphorylation PhosphoSitePlus   RLIMS-P 20068038
S526 Phosphorylation Q99759 (MAP3K3) PhosphoSitePlus   RLIMS-P   Signor 16407301
T528 Phosphorylation PhosphoSitePlus
T530 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S130 Phosphorylation HPRD 18691976
S131 Phosphorylation HPRD 18691976
S145 Phosphorylation HPRD 18691976
S166 Phosphorylation P17612 (PRKACA) HPRD 19651622, 18691976, 12392720
S168 Phosphorylation HPRD 18691976
S175 Phosphorylation HPRD 18691976, 20058876
S176 Phosphorylation HPRD 20058876
S234 Phosphorylation HPRD 18691976
S237 Phosphorylation HPRD 18691976
S250 Phosphorylation HPRD 18691976
Y288 Phosphorylation HPRD 17924679
S289 Phosphorylation HPRD 17924679
T294 Phosphorylation HPRD 17924679
S314 Phosphorylation HPRD 18691976
S337 Phosphorylation P17612 (PRKACA) HPRD 18691976, 12392720
S340 Phosphorylation HPRD 19413330, 18691976
T353 Phosphorylation HPRD 18691976
S355 Phosphorylation HPRD 18691976
S526 Phosphorylation Q99759 (MAP3K3) HPRD 16407301
Site PTM Type PTM Enzyme Score Source PMID
S55 Phosphorylation PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
S161 Phosphorylation HPRD 18691976
S162 Phosphorylation HPRD 18691976
S176 Phosphorylation HPRD 18691976
S197 Phosphorylation P17612 (PRKACA) HPRD 19651622, 18691976, 12392720
S199 Phosphorylation HPRD 18691976
S206 Phosphorylation HPRD 18691976, 20058876
S207 Phosphorylation HPRD 20058876
S265 Phosphorylation HPRD 18691976
S268 Phosphorylation HPRD 18691976
S281 Phosphorylation HPRD 18691976
Y319 Phosphorylation HPRD 17924679
S320 Phosphorylation HPRD 17924679
T325 Phosphorylation HPRD 17924679
S345 Phosphorylation HPRD 18691976
S368 Phosphorylation P17612 (PRKACA) HPRD 18691976, 12392720
S371 Phosphorylation HPRD 19413330, 18691976
T384 Phosphorylation HPRD 18691976
S386 Phosphorylation HPRD 18691976
S557 Phosphorylation Q99759 (MAP3K3) HPRD 16407301


Q99759 (MAP3K3) as PTM Enzyme



Substrate Site Score Source PMID
P46734 (MAP2K3) S218 Signor 9162092
P53805 (RCAN1) S163 PhosphoSitePlus 16126726
P53805 (RCAN1) S167 PhosphoSitePlus   Signor 16126726, 12809556
Q99759-1 (MAP3K3) S526 HPRD   Signor 16407301
Q99759-2 (MAP3K3) S557 HPRD 16407301


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S166 A166 Biomuta DOID:1909 / melanoma [ cosmic ]
S166 P166 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S168 R168 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S168 T168 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S234 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y266 C266 Biomuta DOID:363 / uterine cancer [ tcga ]
K404 N404 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S520 L520 Biomuta DOID:5041 / esophageal cancer [ icgc ]