Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99755 / PI51A_HUMAN
Protein Name Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Gene Name Name: PIP5K1A
Organism Homo sapiens (Human)

PRO ID PR:Q99755
DAG View
PRO Name phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (human)
Definition A phosphatidylinositol 4-phosphate 5-kinase type-1 alpha that is encoded in the genome of human.
Short Label hPIP5K1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99755 (PIP5K1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K86 Methylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
R373 Methylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
T482 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus   UniProt 23186163
S488 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
T540 Phosphorylation PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y333 Phosphorylation HPRD 18707149
S445 Phosphorylation HPRD 19651622, 18691976
T503 Phosphorylation HPRD 20068231
S510 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K456 N456 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S458 F458 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S475 F475 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S486 L486 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S534 * Biomuta DOID:5041 / esophageal cancer [ icgc ]