iPTMnet Report for Q99741 (CDC6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99741 / CDC6_HUMAN
Protein Name Cell division control protein 6 homolog
Gene Name Name: CDC6
Synonyms:CDC18L;
Organism Homo sapiens (Human)

PRO ID PR:Q99741
DAG View
PRO Name cell division control protein 6 homolog (human)
Definition A cell division control protein 6 that is encoded in the genome of human.
Short Label hCDC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99741 (CDC6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S6 Phosphorylation RLIMS-P 19154794
S20 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S30 Phosphorylation RLIMS-P 28447620
K33 Ubiquitination PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 21041660
T37 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 21041660
T43 Phosphorylation HPRD   PhosphoSitePlus 19664995
S45 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18691976, ...19664995, 18669648, 20068231
K49 Ubiquitination PhosphoSitePlus
S54 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 24216307, 22201124, ...27207654, 25875233, 9889196, 10214964, 23479742, 26818844, 30158672, 23129444, 10339564, 20068231, 16055707
S54 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   Signor 18691976, 10339564, 23129444, ...24216307, 9889196, 20068231
T67 Phosphorylation PhosphoSitePlus
S74 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27246979, 22201124, 23129444, ...9889196, 23479742, 26818844, 24216307, 10339564
S74 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   Signor 23129444, 24216307, 10339564, ...9889196
S88 Phosphorylation PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
S106 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 22201124, 22179839, ...25875233, 23479742, 26818844, 23129444, 10339564
S106 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   Signor 10339564, 23129444
K109 Acetylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S127 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S134 Phosphorylation PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
C156 Methylation IEDB 31844290
T166 Phosphorylation HPRD   PhosphoSitePlus 17924679
K194 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
C376 Methylation IEDB 31844290
K379 Ubiquitination PhosphoSitePlus
S381 Phosphorylation HPRD   PhosphoSitePlus 20068231
S384 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S419 Phosphorylation HPRD   PhosphoSitePlus 20068231
S421 Phosphorylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
C493 Methylation IEDB 31844290
K495 Ubiquitination PhosphoSitePlus
C506 Methylation IEDB 31844290
T527 Phosphorylation RLIMS-P 28447620
K531 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046665 (hCDC6/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 T6 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S45 C45 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K92 N92 Biomuta DOID:363 / uterine cancer [ icgc ]
K105 R105 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K220 N220 Biomuta DOID:1612 / breast cancer [ cosmic ]
S384 L384 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K484 E484 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]