iPTMnet Report for Q99728 (BARD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99728 / BARD1_HUMAN
Protein Name BRCA1-associated RING domain protein 1
Gene Name Name: BARD1
Organism Homo sapiens (Human)

PRO ID PR:Q99728
DAG View
PRO Name BRCA1-associated RING domain protein 1 (human)
Definition A BRCA1-associated RING domain protein 1 that is encoded in the genome of human.
Short Label hBARD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99728 (BARD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K46 Sumoylation PhosphoSitePlus
S103 O-Glycosylation GlyGen 30379171
K110 Ubiquitination PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K144 Sumoylation PhosphoSitePlus
S148 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus 15665273, 18669648
K152 Acetylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K170 Sumoylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus   UniProt 23186163
S192 Phosphorylation PhosphoSitePlus
K217 Sumoylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S251 Phosphorylation P06493 (CDK1) , P24941 (CDK2) neXtProt   PhosphoSitePlus 15665273
S288 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   PhosphoSitePlus 15665273
T299 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   PhosphoSitePlus   UniProt 15665273, 23186163
K305 Sumoylation PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S330 Phosphorylation IEDB   PhosphoSitePlus 31848261
S342 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K371 Acetylation PhosphoSitePlus
S391 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T394 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T398 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K423 Sumoylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
T430 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
K548 Sumoylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
T714 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 18842000
T719 Phosphorylation PhosphoSitePlus
T734 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 18842000
Site PTM Type PTM Enzyme Score Source PMID
S148 Phosphorylation HPRD 15855157, 18669648, 20068231
S184 Phosphorylation HPRD 15855157
S186 Phosphorylation HPRD 15855157, 20068231
S251 Phosphorylation HPRD 15855157
T299 Phosphorylation HPRD 15855157
S330 Phosphorylation HPRD 20068231
S364 Phosphorylation HPRD 19413330
S391 Phosphorylation HPRD 15855157, 18669648, 20068231
T394 Phosphorylation HPRD 15855157, 18669648, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046461 (hBARD1/Phos:1) pT714,pT734 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P19838 (NFKB1) S337 Q99728 (BARD1) increased_association eFIP 33024116


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K110 N110 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K124 T124 Biomuta DOID:1319 / brain cancer [ icgc ]
K144 N144 Biomuta [ cosmic ]
S184 F184 Biomuta DOID:4159 / skin cancer [ cosmic ]
S186 G186 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S186 N186 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S186 T186 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S192 F192 Biomuta DOID:1324 / lung cancer [ icgc ]
K217 T217 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K224 N224 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K224 Q224 Biomuta DOID:363 / uterine cancer [ icgc ]
S288 C288 Biomuta DOID:1319 / brain cancer [ cosmic ]
K305 T305 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y307 N307 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S313 Y313 Biomuta DOID:363 / uterine cancer [ icgc ]
S330 I330 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S344 R344 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S364 L364 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S364 T364 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T394 A394 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K484 E484 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S586 I586 Biomuta DOID:1324 / lung cancer [ cosmic ]
K596 R596 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K650 T650 Biomuta DOID:263 / kidney cancer [ cosmic ]
S704 I704 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S704 R704 Biomuta DOID:263 / kidney cancer [ icgc ]
T719 R719 Biomuta DOID:1612 / breast cancer [ cosmic ]