iPTMnet Report for Q99717 (SMAD5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99717 / SMAD5_HUMAN
Protein Name Mothers against decapentaplegic homolog 5
Gene Name Name: SMAD5
Synonyms:MADH5;
Organism Homo sapiens (Human)

PRO ID PR:Q99717
DAG View
PRO Name mothers against decapentaplegic homolog 5 (human)
Definition A smad5 that is encoded in the genome of human.
Short Label hSMAD5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99717 (SMAD5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 22223895
S12 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S58 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S63 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
S100 O-Glycosylation GlyGen 30379171
K117 Sumoylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation phospho.ELM 12601080
S133 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S152 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S462 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
S463 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 35573984, 19413330, 17081983, ...19651622, 28542453, 20068231
S465 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 35573984, 19413330, 17081983, ...19664995, 19651622, 17322306, 18669648, 28542453, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S463 Phosphorylation PRO 8637600, 8673135
S465 Phosphorylation PRO 8637600, 8673135


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049290 (hSMAD5/InitMet-/Phos:1) pS463,pS465 PRO
PR:000036562 (hSMAD5/iso:1/Phos:1) pS463,pS465 PRO 8637600, 8673135


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K22 T22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K119 R119 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S152 C152 Biomuta DOID:4159 / skin cancer [ cosmic ]
K418 R418 Biomuta DOID:4159 / skin cancer [ cosmic ]
S462 F462 Biomuta DOID:4362 / cervical cancer [ icgc ]
S463 F463 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S465 L465 Biomuta DOID:4362 / cervical cancer [ cosmic ]