iPTMnet Report for Q99707 (MTR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99707 / METH_HUMAN
Protein Name Methionine synthase
Gene Name Name: MTR
Organism Homo sapiens (Human)

PRO ID PR:Q99707
DAG View
PRO Name methionine synthase (human)
Definition A methionine synthase that is encoded in the genome of human.
Short Label hMTR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99707 (MTR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
T152 O-Glycosylation GlyGen 29351928
K231 Ubiquitination PhosphoSitePlus
C277 Methylation IEDB 31844290
K309 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
Y491 Phosphorylation PhosphoSitePlus
C516 Methylation IEDB 31844290
Y520 Phosphorylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
Y701 Phosphorylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
T758 Phosphorylation PhosphoSitePlus
T764 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
C812 Methylation IEDB 31844290
K814 Ubiquitination PhosphoSitePlus
K817 Methylation PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
K871 Ubiquitination PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
Y905 Phosphorylation PhosphoSitePlus
Y913 Phosphorylation PhosphoSitePlus
Y921 Phosphorylation PhosphoSitePlus
K925 Ubiquitination PhosphoSitePlus
Y929 Phosphorylation PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
K1000 Ubiquitination PhosphoSitePlus
K1008 Ubiquitination PhosphoSitePlus
Y1010 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
K1024 Ubiquitination PhosphoSitePlus
K1071 Ubiquitination PhosphoSitePlus
K1127 Ubiquitination PhosphoSitePlus
R1132 Methylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
K1169 Ubiquitination PhosphoSitePlus
K1186 Ubiquitination PhosphoSitePlus
S1206 Phosphorylation PhosphoSitePlus
Y1219 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus
K1226 Ubiquitination PhosphoSitePlus
K1232 Ubiquitination PhosphoSitePlus
K1235 Ubiquitination PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T17 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K151 N151 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K309 N309 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K339 T339 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K339 N339 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K475 N475 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y491 H491 Biomuta DOID:4159 / skin cancer [ cosmic ]
K814 N814 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K871 Q871 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1010 H1010 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1010 C1010 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1024 T1024 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
R1132 L1132 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1132 Q1132 Biomuta DOID:363 / uterine cancer [ icgc ]
R1132 W1132 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1206 L1206 Biomuta DOID:4159 / skin cancer [ cosmic ]