iPTMnet Report for Q99704 (DOK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99704 / DOK1_HUMAN
Protein Name Docking protein 1
Gene Name Name: DOK1
Organism Homo sapiens (Human)

PRO ID PR:Q99704
DAG View
PRO Name docking protein 1 (human)
Definition A docking protein 1 that is encoded in the genome of human.
Short Label hDOK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99704 (DOK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19481542, 22814378
Y30 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
R39 Methylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus   UniProt 23186163
R54 Methylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation phospho.ELM   PhosphoSitePlus 11042170
Y203 Phosphorylation phospho.ELM 12087092
S217 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S269 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16094384, 18669648, ...18088087, 19690332
S281 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S291 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y296 Phosphorylation phospho.ELM   PhosphoSitePlus 10688886, 12087092
C308 S-Nitrosylation dbSNO 26338901
S310 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
Y315 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 10688886, 12087092
S316 Phosphorylation PhosphoSitePlus
Y337 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 15546884, 16497976
Y341 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 12087092
T354 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation P00519 (ABL1) , P06213 (INSR) , Q13882 (PTK6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 16094384, 25043303, 12087092, ...15148308, 24523872, 10688886, 15592455, 11551902, 19690332
Y377 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 10688886, 12087092, ...16094384
K394 Ubiquitination PhosphoSitePlus
Y398 Phosphorylation P07949 (RET) , P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16094384, 12087092, 10688886, ...16153436, 15592455, 11551902
Y402 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T406 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 10688886, 12087092, ...16094384
T435 Phosphorylation PhosphoSitePlus
S439 Phosphorylation O14920 (IKBKB) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15574499
S443 Phosphorylation O14920 (IKBKB) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 15574499
S446 Phosphorylation O14920 (IKBKB) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15574499
Y449 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 15659558, 16094384, 10852966, ...12087092, 18083107, 15592455, 12522270
S450 Phosphorylation O14920 (IKBKB) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15574499
S458 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus   UniProt 23186163
T470 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y146 Phosphorylation HPRD 11042170
Y174 Phosphorylation P06239 (LCK) HPRD 10799545
S269 Phosphorylation HPRD 19651622, 18669648, 18088087, ...16094384
S281 Phosphorylation HPRD 18669648
S291 Phosphorylation HPRD 18669648, 15570572
Y296 Phosphorylation HPRD 16497976
S310 Phosphorylation HPRD 18077418
Y315 Phosphorylation HPRD 18083107, 16497976
Y337 Phosphorylation HPRD 19901323, 16497976
Y341 Phosphorylation HPRD 19901323, 16497976
Y362 Phosphorylation P06213 (INSR) HPRD 11551902, 16497976
Y377 Phosphorylation HPRD 15570572, 16497976
Y398 Phosphorylation P06213 (INSR) , P07949 (RET) HPRD 19901323, 11551902, 16497976
Y402 Phosphorylation HPRD 15592455, 16497976
Y409 Phosphorylation HPRD 17016520, 19901323, 15144186, ...16497976
Y449 Phosphorylation HPRD 19901323, 12522270, 16497976, ...18707149
S450 Phosphorylation HPRD 15144186


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047203 (hDOK1/Phos:1) pY362 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99704 (DOK1) Y449 O60880 (SH2D1A) unknown eFIP 10852966


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K46 N46 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
R54 Q54 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y174 H174 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S310 F310 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S316 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y377 H377 Biomuta DOID:363 / uterine cancer [ icgc ]
T435 I435 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S460 I460 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T470 N470 Biomuta DOID:4606 / bile duct cancer [ cosmic ]