iPTMnet Report for Q99700 (ATXN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99700 / ATX2_HUMAN
Protein Name Ataxin-2
Gene Name Name: ATXN2
Synonyms:ATX2,SCA2,TNRC13;
Organism Homo sapiens (Human)

PRO ID PR:Q99700
DAG View
PRO Name ataxin-2 (human)
Definition An ataxin-2 that is encoded in the genome of human.
Short Label hATXN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99700 (ATXN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R2 Methylation PhosphoSitePlus
S3 Phosphorylation PhosphoSitePlus
R9 Methylation PhosphoSitePlus
R40 Methylation PhosphoSitePlus
Y156 Phosphorylation IEDB 32387766
S213 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S215 O-Glycosylation GlyGen 28604694
S216 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S217 O-Glycosylation GlyGen 28604694
S218 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S220 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S221 O-Glycosylation GlyGen 28604694
S222 O-Glycosylation GlyGen 28604694
S223 O-Glycosylation GlyGen 28604694
R239 Methylation PhosphoSitePlus
R244 Methylation PhosphoSitePlus
R246 Methylation PhosphoSitePlus
S248 Phosphorylation HPRD   PhosphoSitePlus 20068231
S255 Phosphorylation HPRD 20068231
T256 Phosphorylation HPRD 20068231
S258 Phosphorylation HPRD 20068231
Y263 Phosphorylation PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
C301 S-Nitrosylation dbSNO 19483679, 24105792
K311 Ubiquitination PhosphoSitePlus
S327 Phosphorylation HPRD   PhosphoSitePlus 20068231
C332 Methylation IEDB 31844290
Y347 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S393 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S431 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
R465 Methylation PhosphoSitePlus
S466 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18669648, 23186163
K470 Ubiquitination PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
S478 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
S505 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus   UniProt 23186163
R510 Methylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
R515 Methylation PhosphoSitePlus
S521 Phosphorylation HPRD   PhosphoSitePlus 20068231
S523 Phosphorylation PhosphoSitePlus
S526 Phosphorylation HPRD   PhosphoSitePlus 20068231
S528 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...35254053, 30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S528 Phosphorylation PhosphoSitePlus
T529 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S530 Phosphorylation PhosphoSitePlus
S533 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S541 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S554 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S558 Phosphorylation HPRD   PhosphoSitePlus 18669648
S560 Phosphorylation phospho.ELM 18669648
S561 Phosphorylation HPRD 18669648
S565 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
R622 Methylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R635 Methylation PhosphoSitePlus
S637 Phosphorylation HPRD   PhosphoSitePlus 20068231
R640 Methylation PhosphoSitePlus   UniProt 24129315
S642 Phosphorylation PhosphoSitePlus   UniProt 23186163
T660 Phosphorylation PhosphoSitePlus
R665 Methylation PhosphoSitePlus
T666 O-Glycosylation GlyGen 33214551, 32938750, 35138101, ...35254053, 30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
T666 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 19664995, ...20068231
S667 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20058876, 19664995, ...18452278, 19651622, 18669648, 20068231
S669 Phosphorylation HPRD   PhosphoSitePlus 19664995
T672 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S674 Phosphorylation PhosphoSitePlus
S675 O-Glycosylation GlyGen 31373491
S678 Phosphorylation PhosphoSitePlus
S684 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19651622, 18669648, ...19690332, 20068231
S692 Phosphorylation IEDB   PhosphoSitePlus 30784271, 29493099, 33936100
S697 Phosphorylation PhosphoSitePlus
S728 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 24275569
T730 Phosphorylation HPRD   PhosphoSitePlus 18669648
S733 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
T741 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18669648
S743 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S744 Phosphorylation HPRD   PhosphoSitePlus 18669648
S749 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
T771 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17287340, 17322306, ...20068231, 17924679
S772 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 17322306, 17287340, ...18767875, 19651622, 23186163, 20068231, 17924679
S774 Phosphorylation HPRD   PhosphoSitePlus 20068231
S776 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...30397120, 30379171, 34725712, 34019948, 21740066, 30059200, 35132862, 30620550, 28604694, 31492838, 20305658, 32119511, 29351928, 28657654, 29237092
S776 Phosphorylation HPRD   PhosphoSitePlus 17924679
K781 Ubiquitination PhosphoSitePlus
S784 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...18220336, 19664995, 17322306, 20068231
S788 Phosphorylation PhosphoSitePlus
S809 O-Glycosylation GlyGen 31373491
T811 Phosphorylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
S828 Phosphorylation HPRD   PhosphoSitePlus 17287340
S839 Phosphorylation HPRD   PhosphoSitePlus 17287340
S848 Phosphorylation phospho.ELM 18669648
S849 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17081983
S850 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
T853 Phosphorylation HPRD 17081983
S854 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17081983
S856 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S857 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18669648
S861 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 19651622, ...18669648, 20068231
S863 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18669648, 17081983, ...20068231
S865 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...19651622, 18669648, 20068231
S867 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983
S870 Phosphorylation HPRD   PhosphoSitePlus 20068231
T872 Phosphorylation PhosphoSitePlus
T887 Phosphorylation PhosphoSitePlus
S888 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S889 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18669648, 19664994, ...20068231
K911 Ubiquitination PhosphoSitePlus
T913 Phosphorylation PhosphoSitePlus
T934 Phosphorylation PhosphoSitePlus
R998 Methylation PhosphoSitePlus
Y1105 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R246 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S248 N248 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T256 K256 Biomuta DOID:4159 / skin cancer [ cosmic ]
S298 G298 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C301 F301 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K311 R311 Biomuta DOID:1324 / lung cancer [ cosmic ]
K361 N361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S505 F505 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S513 L513 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R515 P515 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S521 L521 Biomuta DOID:363 / uterine cancer [ icgc ]
S565 F565 Biomuta DOID:4159 / skin cancer [ cosmic ]
S624 F624 Biomuta DOID:4159 / skin cancer [ cosmic ]
S637 F637 Biomuta DOID:4159 / skin cancer [ cosmic ]
R640 M640 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S669 L669 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T730 M730 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S736 W736 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S749 F749 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
S776 L776 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S809 R809 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S814 Y814 Biomuta DOID:363 / uterine cancer [ icgc ]
K821 N821 Biomuta DOID:363 / uterine cancer [ icgc ]
S828 L828 Biomuta DOID:4159 / skin cancer [ cosmic ]
S854 I854 Biomuta DOID:363 / uterine cancer [ icgc ]
S865 F865 Biomuta DOID:4159 / skin cancer [ cosmic ]
S867 L867 Biomuta DOID:1612 / breast cancer [ cosmic ]
S889 N889 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T934 A934 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]