Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99700 / ATX2_HUMAN
Protein Name Ataxin-2
Gene Name Name: ATXN2
Synonyms:ATX2,SCA2,TNRC13;
Organism Homo sapiens (Human)

PRO ID PR:Q99700
DAG View
PRO Name ataxin-2 (human)
Definition An ataxin-2 that is encoded in the genome of human.
Short Label hATXN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99700 (ATXN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R2 Methylation PhosphoSitePlus
S3 Phosphorylation PhosphoSitePlus
R9 Methylation PhosphoSitePlus
R40 Methylation PhosphoSitePlus
R244 Methylation PhosphoSitePlus
R246 Methylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
C301 S-Nitrosylation dbSNO 19483679, 24105792
K311 Ubiquitination PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus   UniProt 20068231
S431 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
R465 Methylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
K470 Ubiquitination PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus   UniProt 23186163
S505 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus   UniProt 23186163
R510 Methylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
R515 Methylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus   UniProt 18669648
S558 Phosphorylation PhosphoSitePlus
S560 Phosphorylation phospho.ELM 18669648
S565 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
R622 Methylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R635 Methylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
R640 Methylation PhosphoSitePlus   UniProt 24129315
S642 Phosphorylation PhosphoSitePlus   UniProt 23186163
T660 Phosphorylation PhosphoSitePlus
R665 Methylation PhosphoSitePlus
T666 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S692 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus   UniProt 24275569
T730 Phosphorylation PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
T741 Phosphorylation PhosphoSitePlus   UniProt 18669648
S743 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S744 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
T771 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus   UniProt 23186163
S774 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231, ...18220336
S788 Phosphorylation PhosphoSitePlus
T811 Phosphorylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
S848 Phosphorylation phospho.ELM 18669648
S849 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S856 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S857 Phosphorylation PhosphoSitePlus   UniProt 18669648
S861 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
S863 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus   UniProt 21406692
S867 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
T872 Phosphorylation PhosphoSitePlus
T887 Phosphorylation PhosphoSitePlus
S888 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S889 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
K911 Ubiquitination PhosphoSitePlus
T913 Phosphorylation PhosphoSitePlus
T934 Phosphorylation PhosphoSitePlus
R998 Methylation PhosphoSitePlus
Y1105 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S248 Phosphorylation HPRD 20068231
S255 Phosphorylation HPRD 20068231
T256 Phosphorylation HPRD 20068231
S258 Phosphorylation HPRD 20068231
S327 Phosphorylation HPRD 20068231
S393 Phosphorylation HPRD 20068231
S466 Phosphorylation HPRD 19651622, 18669648
S478 Phosphorylation HPRD 18669648
S521 Phosphorylation HPRD 20068231
S526 Phosphorylation HPRD 20068231
S554 Phosphorylation HPRD 18669648
S558 Phosphorylation HPRD 18669648
S561 Phosphorylation HPRD 18669648
S637 Phosphorylation HPRD 20068231
T666 Phosphorylation HPRD 19651622, 18669648, 19664995, ...20068231
S667 Phosphorylation HPRD 19413330, 20058876, 19664995, ...18452278, 19651622, 18669648, 20068231
S669 Phosphorylation HPRD 19664995
T672 Phosphorylation HPRD 18669648, 20068231
S684 Phosphorylation HPRD 19651622, 18669648, 20068231
S728 Phosphorylation HPRD 18669648
T730 Phosphorylation HPRD 18669648
T741 Phosphorylation HPRD 19651622, 18669648
S743 Phosphorylation HPRD 18669648
S744 Phosphorylation HPRD 18669648
T771 Phosphorylation HPRD 17322306, 19651622, 17287340, ...20068231, 17924679
S772 Phosphorylation HPRD 19413330, 17322306, 17287340, ...18767875, 19651622, 20068231, 17924679
S774 Phosphorylation HPRD 20068231
S776 Phosphorylation HPRD 17924679
S784 Phosphorylation HPRD 17322306, 19651622, 19664995, ...20068231
S828 Phosphorylation HPRD 17287340
S839 Phosphorylation HPRD 17287340
S849 Phosphorylation HPRD 18669648, 17081983
S850 Phosphorylation HPRD 17081983, 20068231
T853 Phosphorylation HPRD 17081983
S854 Phosphorylation HPRD 18669648, 17081983
S856 Phosphorylation HPRD 18669648, 20068231
S857 Phosphorylation HPRD 19413330, 18669648
S861 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S863 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S865 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S867 Phosphorylation HPRD 19651622, 17081983
S870 Phosphorylation HPRD 20068231
S888 Phosphorylation HPRD 18669648
S889 Phosphorylation HPRD 18669648, 19664994, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R246 * Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1319 / brain cancer [ icgc ]
S248 N248 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S298 G298 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
C301 F301 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K311 R311 Biomuta DOID:1324 / lung cancer [ cosmic ]
S356 C356 Biomuta DOID:363 / uterine cancer [ tcga ]
K361 N361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S393 C393 Biomuta DOID:5041 / esophageal cancer [ tcga ]
Y454 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y471 * Biomuta DOID:3571 / liver cancer [ icgc ]
S478 Y478 Biomuta DOID:3571 / liver cancer [ icgc ]
S505 F505 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S513 L513 Biomuta DOID:1909 / melanoma [ tcga ]
R515 P515 Biomuta DOID:1324 / lung cancer [ tcga ]
S521 L521 Biomuta DOID:363 / uterine cancer [ tcga ]
R635 I635 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R640 M640 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S669 L669 Biomuta DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T672 M672 Biomuta DOID:363 / uterine cancer [ tcga ]
T730 M730 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S776 L776 Biomuta DOID:4362 / cervical cancer [ tcga ]
S814 Y814 Biomuta DOID:363 / uterine cancer [ tcga ]
K821 N821 Biomuta DOID:363 / uterine cancer [ tcga ]
S854 I854 Biomuta DOID:363 / uterine cancer [ tcga ]
T934 A934 Biomuta DOID:363 / uterine cancer [ tcga ]