iPTMnet Report for Q99698 (LYST)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99698 / LYST_HUMAN
Protein Name Lysosomal-trafficking regulator
Gene Name Name: LYST
Synonyms:CHS,CHS1;
Organism Homo sapiens (Human)

PRO ID PR:Q99698
DAG View
PRO Name lysosomal-trafficking regulator (human)
Definition A lysosomal-trafficking regulator that is encoded in the genome of human.
Short Label hLYST
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99698 (LYST) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S154 Phosphorylation PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
K351 Acetylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
T822 Phosphorylation IEDB 32387766
K979 Methylation PhosphoSitePlus
S1054 Phosphorylation PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
T1119 Phosphorylation PhosphoSitePlus
S1194 Phosphorylation PhosphoSitePlus
S1195 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus
K1305 Ubiquitination PhosphoSitePlus
S1489 Phosphorylation PhosphoSitePlus
T1490 Phosphorylation PhosphoSitePlus
T1491 Phosphorylation PhosphoSitePlus
S1503 Phosphorylation PhosphoSitePlus
S1509 Phosphorylation PhosphoSitePlus
S1510 Phosphorylation PhosphoSitePlus
K1622 Acetylation PhosphoSitePlus
K1703 Acetylation PhosphoSitePlus
K1710 Acetylation PhosphoSitePlus
K1791 Ubiquitination PhosphoSitePlus
Y1798 Phosphorylation PhosphoSitePlus
T1982 Phosphorylation PhosphoSitePlus
S2103 Phosphorylation PhosphoSitePlus
S2105 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163
T2111 Phosphorylation PhosphoSitePlus
T2122 Phosphorylation PhosphoSitePlus
S2124 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2128 Phosphorylation PhosphoSitePlus
T2138 Phosphorylation PhosphoSitePlus
Y2139 Phosphorylation PhosphoSitePlus
T2142 Phosphorylation PhosphoSitePlus
S2149 Phosphorylation PhosphoSitePlus
S2152 Phosphorylation PhosphoSitePlus
S2153 O-Glycosylation GlyGen 30379171, 28411811, 29237092
T2155 O-Glycosylation GlyGen 30379171, 28411811, 29237092
T2155 Phosphorylation PhosphoSitePlus
S2166 Phosphorylation PhosphoSitePlus
S2167 Phosphorylation PhosphoSitePlus
S2170 Phosphorylation PhosphoSitePlus
S2186 Phosphorylation PhosphoSitePlus
S2213 Phosphorylation PhosphoSitePlus
S2217 Phosphorylation PhosphoSitePlus
S2235 Phosphorylation PhosphoSitePlus
S2239 Phosphorylation PhosphoSitePlus
T2242 Phosphorylation PhosphoSitePlus
S2264 Phosphorylation PhosphoSitePlus
T2270 Phosphorylation PhosphoSitePlus
Y2358 Phosphorylation PhosphoSitePlus
S2591 Phosphorylation PhosphoSitePlus
S2612 Phosphorylation PhosphoSitePlus
S2627 Phosphorylation PhosphoSitePlus
S2632 Phosphorylation PhosphoSitePlus
S2676 Phosphorylation PhosphoSitePlus
T2707 Phosphorylation PhosphoSitePlus
Y2708 Phosphorylation PhosphoSitePlus
K2726 Ubiquitination PhosphoSitePlus
K2731 Acetylation PhosphoSitePlus
S3022 Phosphorylation PhosphoSitePlus
S3026 Phosphorylation PhosphoSitePlus
K3191 Ubiquitination PhosphoSitePlus
Y3208 Phosphorylation PhosphoSitePlus
Y3210 Phosphorylation PhosphoSitePlus
Y3215 Phosphorylation PhosphoSitePlus
Y3299 Phosphorylation PhosphoSitePlus
Y3457 Phosphorylation PhosphoSitePlus
S3659 Phosphorylation PhosphoSitePlus
T3662 Phosphorylation PhosphoSitePlus
K3749 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2105 Phosphorylation HPRD 18669648, 20058876
T2122 Phosphorylation HPRD 20058876
S2124 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S166 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T193 P193 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S263 P263 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S494 L494 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1061 G1061 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1195 F1195 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S1225 I1225 Biomuta DOID:363 / uterine cancer [ icgc ]
S1489 I1489 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1503 L1503 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1622 N1622 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1982 I1982 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T2138 N2138 Biomuta DOID:1319 / brain cancer [ icgc ]
S2149 C2149 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2149 Y2149 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S2152 C2152 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2153 F2153 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S2235 F2235 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2264 G2264 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2627 T2627 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2676 I2676 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y2708 H2708 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3022 C3022 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y3299 C3299 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]