iPTMnet Report for Q99683 (MAP3K5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99683 / M3K5_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 5
Gene Name Name: MAP3K5
Synonyms:ASK1,MAPKKK5,MEKK5;
Organism Homo sapiens (Human)

PRO ID PR:Q99683
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 5 (human)
Definition A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of human.
Short Label hMAP3K5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99683 (MAP3K5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R78 Methylation UniProt 22095282
R80 Methylation UniProt 22095282
S82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 26661061, 26912789, 32111229, ...25982447, 12697749, 20112989, 16098218, 14500571, 22194952, 23608533, 15782121, 16532036, 19749799, 11154276, 23476679, 15242986, 15911620
S83 Phosphorylation P11309 (PIM1) neXtProt   PhosphoSitePlus   Signor 19749799
S83 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 11154276, 14500571, 15782121, ...16532036, 15911620
S83 Phosphorylation P31751 (AKT2) neXtProt   PhosphoSitePlus   Signor 12697749
S83 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 23608533
R89 Methylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
C120 Methylation IEDB 31844290
S461 Phosphorylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
K535 Sumoylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
Y574 Phosphorylation PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
Y718 Phosphorylation IntAct   neXtProt   PhosphoSitePlus   Signor   UniProt 16407264, 19287004
Y718 Phosphorylation O60674 (JAK2) neXtProt   PhosphoSitePlus   Signor 19287004
Y718 Phosphorylation P23458 (JAK1) PhosphoSitePlus 19287004
K730 Ubiquitination PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
T813 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17937911
T813 Phosphorylation Q99683 (MAP3K5) neXtProt   PhosphoSitePlus   Signor   UniProt 17937911
Y814 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus
T825 Phosphorylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
T838 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28600984, 19590015, 23102700, ...20112989, 19805025, 9564042, 17937911, 11920685, 19570911, 31926625, 19935702, 15755722, 19920149, 17210579, 18948261
T838 Phosphorylation O95382 (MAP3K6) neXtProt   Signor 17210579
T838 Phosphorylation Q14680 (MELK) neXtProt 18948261
T838 Phosphorylation Q15139 (PRKD1) PhosphoSitePlus 15755722
T838 Phosphorylation Q99683 (MAP3K5) neXtProt   PhosphoSitePlus   Signor   UniProt 9564042, 17937911, 19920149, ...11920685
T842 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17937911, 11920685
T842 Phosphorylation Q99683 (MAP3K5) neXtProt   PhosphoSitePlus   Signor   UniProt 17937911
C869 S-Nitrosylation dbSNO 22178444, 14668338, 15688001
K946 Acetylation PhosphoSitePlus
S958 Phosphorylation PhosphoSitePlus   UniProt 23186163
S964 Phosphorylation PhosphoSitePlus
S966 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22276160, 15094778, 16648474, ...26095851, 14688258, 19590015, 19920149, 10411906
S966 Phosphorylation O15530 (PDPK1) neXtProt   PhosphoSitePlus 19920149
S966 Phosphorylation Q99683 (MAP3K5) phospho.ELM   PhosphoSitePlus   UniProt 19920149, 14688258, 10411906, ...16648474
Y982 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
S997 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087
S1033 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18088087, 15094778, ...18669648, 19590015
T1059 Phosphorylation PhosphoSitePlus
K1064 Ubiquitination PhosphoSitePlus
K1083 Sumoylation PhosphoSitePlus
T1109 Phosphorylation PhosphoSitePlus   RLIMS-P 23608533
T1109 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 23608533
K1114 Sumoylation PhosphoSitePlus
S1234 Phosphorylation IEDB 32897882
S1240 Phosphorylation PhosphoSitePlus
T1326 Phosphorylation PhosphoSitePlus   RLIMS-P 23608533
T1326 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 23608533
Site PTM Type PTM Enzyme Score Source PMID
S83 Phosphorylation HPRD 11154276
S83 Phosphorylation P31749 (AKT1) HPRD 11154276
T838 Phosphorylation HPRD 11920685
T838 Phosphorylation Q99683 (MAP3K5) HPRD 11920685
T842 Phosphorylation HPRD 11920685
S966 Phosphorylation HPRD 10411906
S1029 Phosphorylation HPRD 18691976, 18669648, 18088087
S1033 Phosphorylation HPRD 18669648, 18088087


Q99683 (MAP3K5) as PTM Enzyme



Substrate Site Score Source PMID
O15530 (PDPK1) S394 neXtProt   PhosphoSitePlus 19920149, 22544756
O15530 (PDPK1) S398 neXtProt   PhosphoSitePlus 19920149, 22544756
P38936 (CDKN1A) S98 phospho.ELM   PhosphoSitePlus   Signor 17325029
P45379-11 (TNNT2) T191 HPRD 12819028
P45379-6 (TNNT2) T194 HPRD 12819028
P45379-11 (TNNT2) S195 HPRD 12819028
P45379-6 (TNNT2) S198 HPRD 12819028
P45379-10 (TNNT2) T201 HPRD 12819028
P45379 (TNNT2) T204 neXtProt 12819028
P45379-10 (TNNT2) S205 HPRD 12819028
P45379 (TNNT2) S208 neXtProt 12819028
P45983 (MAPK8) T183 PhosphoSitePlus 19749799
P45983 (MAPK8) Y185 PhosphoSitePlus 19749799
P45985 (MAP2K4) T261 phospho.ELM   PhosphoSitePlus   Signor 8974401, 15911620
P46734 (MAP2K3) S218 PhosphoSitePlus   Signor 19920149
P52564 (MAP2K6) S207 PhosphoSitePlus 19920149
Q16539 (MAPK14) T180 PhosphoSitePlus 19749799
Q16539 (MAPK14) Y182 PhosphoSitePlus 19749799
Q969S3 (ZNF622) S314 neXtProt   PhosphoSitePlus   Signor 21771788
Q969S3 (ZNF622) T318 neXtProt   PhosphoSitePlus   Signor 21771788
Q99683 (MAP3K5) T813 neXtProt   PhosphoSitePlus   Signor   UniProt 17937911
Q99683 (MAP3K5) T838 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 9564042, 17937911, 19920149, ...11920685
Q99683 (MAP3K5) T842 neXtProt   PhosphoSitePlus   Signor   UniProt 17937911
Q99683 (MAP3K5) S966 phospho.ELM   PhosphoSitePlus   UniProt 19920149, 14688258, 10411906, ...16648474
Q9UER7 (DAXX) S176 PhosphoSitePlus   Signor 19789334, 19789335
Q9UER7 (DAXX) S184 PhosphoSitePlus   Signor 19789334, 19789335
Q9Y3F4 (STRAP) T175 PhosphoSitePlus 19880523
Q9Y3F4 (STRAP) S179 PhosphoSitePlus 19880523


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99683 (MAP3K5) S83 P11309 (PIM1) unknown eFIP 19749799
Phosphorylation Q99683 (MAP3K5) S83 P31749 (AKT1) decreased_association eFIP 26912789