Protein Information

Cytoscape View

UniProt AC / UniProt ID Q99665 / I12R2_HUMAN
Protein Name Interleukin-12 receptor subunit beta-2 precursor
Gene Name Name: IL12RB2
Organism Homo sapiens (Human)

PRO ID PR:Q99665
DAG View
PRO Name interleukin-12 receptor subunit beta-2 (human)
Definition An interleukin-12 receptor subunit beta-2 that is encoded in the genome of human.
Short Label hIL12RB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q99665 (IL12RB2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T390 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
Y800 Phosphorylation IntAct   UniProt 10415122, 14559241, 9890938
S859 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S749 Phosphorylation HPRD 20058876

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99665 (IL12RB2) Y800 Q14765 (STAT4) unknown eFIP 10415122
Phosphorylation Q99665 (IL12RB2) Y800 O14543 (SOCS3) unknown eFIP 14559241
Phosphorylation Q99665 (IL12RB2) Y800 Q14765 (STAT4) unknown eFIP 9890938

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S630 N630 Biomuta DOID:3070 / malignant glioma [ tcga ]
S749 T749 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K768 N768 Biomuta DOID:263 / kidney cancer [ tcga ]
K768 E768 Biomuta DOID:11934 / head and neck cancer [ tcga ]