iPTMnet Report for Q99640 (PKMYT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99640 / PMYT1_HUMAN
Protein Name Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Gene Name Name: PKMYT1
Synonyms:MYT1;
Organism Homo sapiens (Human)

PRO ID PR:Q99640
DAG View
PRO Name membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human)
Definition A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase that is encoded in the genome of human.
Short Label hPKMYT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99640 (PKMYT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
M1 Acetylation UniProt 20068231
T17 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
T24 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y31 Phosphorylation PhosphoSitePlus
S40 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K42 Methylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
S50 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K58 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
S83 Phosphorylation P31749 (AKT1) , P45983 (MAPK8) neXtProt 11802161, 19204086
S89 Phosphorylation PhosphoSitePlus
S94 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...16565220
Y97 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S109 Phosphorylation PhosphoSitePlus
S120 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K126 Methylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S143 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257
K149 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus   UniProt 20068231
K163 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S426 Phosphorylation P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12738781
S441 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
S469 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163
S473 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S479 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus   UniProt 23186163
T495 Phosphorylation P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 12738781
Site PTM Type PTM Enzyme Score Source PMID
T17 Phosphorylation HPRD 18691976, 18669648, 20068231
S22 Phosphorylation HPRD 20068231
T24 Phosphorylation HPRD 18669648, 20068231
S40 Phosphorylation HPRD 18669648, 20068231
S48 Phosphorylation HPRD 20068231
S50 Phosphorylation HPRD 18669648, 20068231
S60 Phosphorylation HPRD 20068231
S94 Phosphorylation HPRD 18691976, 18669648, 16565220
Y97 Phosphorylation HPRD 18669648
S120 Phosphorylation HPRD 18691976, 18669648, 20068231
S141 Phosphorylation HPRD 18691976, 20068231
S143 Phosphorylation HPRD 18691976, 20068231
S160 Phosphorylation HPRD 18691976, 20068231
S426 Phosphorylation P53350 (PLK1) HPRD 12738781
S454 Phosphorylation HPRD 18691976
S469 Phosphorylation HPRD 18691976, 18669648
S473 Phosphorylation HPRD 18669648
S479 Phosphorylation HPRD 18691976
T495 Phosphorylation P53350 (PLK1) HPRD 12738781, 18691976
Site PTM Type PTM Enzyme Score Source PMID
T17 Phosphorylation HPRD 18691976, 18669648, 20068231
S22 Phosphorylation HPRD 20068231
T24 Phosphorylation HPRD 18669648, 20068231
S40 Phosphorylation HPRD 18669648, 20068231
S48 Phosphorylation HPRD 20068231
S50 Phosphorylation HPRD 18669648, 20068231
S60 Phosphorylation HPRD 20068231
S94 Phosphorylation HPRD 18691976, 18669648, 16565220
Y97 Phosphorylation HPRD 18669648
S120 Phosphorylation HPRD 18691976, 18669648, 20068231
S141 Phosphorylation HPRD 18691976, 20068231
S143 Phosphorylation HPRD 18691976, 20068231
S160 Phosphorylation HPRD 18691976, 20068231


Q99640 (PKMYT1) as PTM Enzyme



Substrate Site Score Source PMID
P06493 (CDK1) T14 HPRD   PhosphoSitePlus   Signor 9001210, 19413330, 21900495, ...18691976, 18452278, 19651622, 9268380, 18669648, 19901323, 10504341, 26673326, 19415658, 20068231, 20068230
P06493 (CDK1) Y15 HPRD   PhosphoSitePlus   Signor 9001210, 17016520, 19413330, ...18691976, 8084605, 20058876, 18452278, 19651622, 9268380, 18669648, 19901323, 10504341, 26673326, 19415658, 20068231, 16497976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048783 (hPKMYT1/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S120 C120 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S143 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
K149 Q149 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K154 Q154 Biomuta DOID:2394 / ovarian cancer [ icgc ]
S454 F454 Biomuta DOID:4159 / skin cancer [ cosmic ]
S473 * Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]