iPTMnet Report for Q99623 (PHB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99623 / PHB2_HUMAN
Protein Name Prohibitin-2
Gene Name Name: PHB2
Synonyms:BAP;
Organism Homo sapiens (Human)

PRO ID PR:Q99623
DAG View
PRO Name prohibitin-2 (human)
Definition A prohibitin-2 that is encoded in the genome of human.
Short Label hPHB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99623 (PHB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K6 Methylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus   RLIMS-P 33820826, 28555617
Y77 Phosphorylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
S91 Phosphorylation P31749 (AKT1) , Q16566 (CAMK4) PhosphoSitePlus   RLIMS-P+   Signor 21689744, 24522204
S92 Phosphorylation PhosphoSitePlus
S96 O-Glycosylation GlyGen 30379171, 30444036, 34725712, ...33214551, 32870666
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
R123 Methylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 15592455, 31165762
S135 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus   UniProt 23186163
T155 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
Y248 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 31165762
K250 Acetylation PhosphoSitePlus   UniProt 19608861
K250 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
R289 Methylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99623 (PHB2) S39 O14965 (AURKA) unknown eFIP 33820826


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y34 C34 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y34 * Biomuta [ cosmic ]
S91 F91 Biomuta DOID:4159 / skin cancer [ cosmic ]
S91 P91 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y121 C121 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R123 C123 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T155 A155 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S176 G176 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T263 M263 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R289 S289 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K296 N296 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]