iPTMnet Report for Q99613 (EIF3C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99613 / EIF3C_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit C
Gene Name Name: EIF3C
Synonyms:EIF3S8;
Organism Homo sapiens (Human)

PRO ID PR:Q99613
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit C (human)
Definition A protein that is a translation product of the EIF3C gene in human.
Short Label hEIF3C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99613 (EIF3C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T7 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S9 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 17322308
S11 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 17322308
S13 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 17322308
S15 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 17322308
S16 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 17322308
S18 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 17322308
T24 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
S39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16097034, 17081983, ...17322308
T45 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
S95 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K99 Ubiquitination PhosphoSitePlus
R104 Methylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
S154 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...33465208, 34019948
K160 Ubiquitination PhosphoSitePlus
S166 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 17081983, ...17322308
S178 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S181 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S182 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S201 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
R288 Methylation PhosphoSitePlus
R303 Methylation PhosphoSitePlus
R305 Methylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K332 Acetylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K513 Acetylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
T524 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 17322308
K531 Ubiquitination PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
R550 Methylation PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
K558 Acetylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
C567 Methylation IEDB 31844290
T612 Phosphorylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
R653 Methylation PhosphoSitePlus
K664 Acetylation PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
K712 Acetylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
R719 Methylation PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
C752 S-Nitrosylation dbSNO 26338901, 22126794
S754 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
K877 Ubiquitination PhosphoSitePlus
T880 Phosphorylation PhosphoSitePlus
Y881 Phosphorylation PhosphoSitePlus
Y884 Phosphorylation PhosphoSitePlus
K889 Ubiquitination PhosphoSitePlus
Y892 Phosphorylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
Y898 Phosphorylation PhosphoSitePlus
R901 Methylation PhosphoSitePlus
Y904 Phosphorylation PhosphoSitePlus
S909 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 17322308
T911 Phosphorylation PhosphoSitePlus
Y913 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation HPRD 18669648, 17081983, 20068231
T7 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S9 Phosphorylation HPRD 18510355, 19651622, 18669648, ...17081983, 18452278
S11 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S13 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S15 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S16 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S18 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S39 Phosphorylation HPRD 19413330, 17322306, 18578522, ...17287340, 16964243, 18767875, 19664994, 19007248, 18452278, 19651622, 18669648, 19664995, 18707149, 18212344, 20068231, 20058876
T45 Phosphorylation HPRD 20068231
S95 Phosphorylation HPRD 17081983
S166 Phosphorylation HPRD 19413330, 17287340, 17081983, ...15302935, 19007248, 18452278, 19651622, 18669648, 20068231
S178 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S181 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S182 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
T446 Phosphorylation HPRD 20068231
T524 Phosphorylation HPRD 15302935, 20068231
S909 Phosphorylation HPRD 16083285, 16964243, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T262 A262 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R288 H288 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R303 K303 Biomuta DOID:3571 / liver cancer [ cosmic ]
R305 L305 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R305 W305 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K331 N331 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]