iPTMnet Report for Q99575 (POP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99575 / POP1_HUMAN
Protein Name Ribonucleases P/MRP protein subunit POP1
Gene Name Name: POP1
Synonyms:KIAA0061;
Organism Homo sapiens (Human)

PRO ID PR:Q99575
DAG View
PRO Name ribonucleases P/MRP protein subunit POP1 (human)
Definition A ribonucleases P/MRP protein subunit POP1 that is encoded in the genome of human.
Short Label hPOP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99575 (POP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation HPRD 20068231
T21 O-Glycosylation GlyGen 33214551, 34019948, 35083852, ...31373491, 35254053
R30 Methylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
T53 Phosphorylation HPRD 20068231
S65 Phosphorylation PhosphoSitePlus
S95 Phosphorylation HPRD   PhosphoSitePlus 18077418
K100 Ubiquitination PhosphoSitePlus
R137 Methylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S355 Phosphorylation HPRD 20068231
T365 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 20068231
S367 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18767875, ...15302935, 17322306, 18669648
S371 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 19007248
T373 Phosphorylation PhosphoSitePlus
K379 Sumoylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
T404 Phosphorylation HPRD   PhosphoSitePlus 17924679
K566 Ubiquitination PhosphoSitePlus
S568 Phosphorylation HPRD   PhosphoSitePlus 20068231
S584 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
K605 Ubiquitination PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
Y722 Phosphorylation PhosphoSitePlus
S726 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648
S729 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18491316, 17081983, ...20058876, 19664995, 18669648, 20068231
S730 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 15302935, 18491316, ...23186163, 17081983, 18767875, 19664994, 19664995, 18452278, 19651622, 17322306, 18669648, 21406692, 19690332, 19415658, 20068231, 19691289
K734 Ubiquitination PhosphoSitePlus
S736 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T761 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
C777 S-Nitrosylation dbSNO 26338901
S792 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S927 Phosphorylation HPRD 20068231
S960 O-Glycosylation GlyGen 31373491
Y1015 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R30 S30 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S36 T36 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K40 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R137 Q137 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
R137 W137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S355 L355 Biomuta DOID:4159 / skin cancer [ cosmic ]
S568 L568 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
K654 R654 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y722 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S730 F730 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K734 M734 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S762 F762 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C777 R777 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C777 Y777 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S792 I792 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S960 C960 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S960 T960 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]