Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99569 / PKP4_HUMAN
Protein Name Plakophilin-4
Gene Name Name: PKP4
Organism Homo sapiens (Human)

PRO ID PR:Q99569
DAG View
PRO Name plakophilin-4 (human)
Definition A plakophilin-4 that is encoded in the genome of human.
Short Label hPKP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99569 (PKP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation PhosphoSitePlus   UniProt 23186163
S77 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus   UniProt 24275569
S92 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y114 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
R207 Methylation PhosphoSitePlus
R211 Methylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
R218 Methylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S223 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S233 Phosphorylation PhosphoSitePlus
R234 Methylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus   UniProt 23186163
R254 Methylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
R270 Methylation PhosphoSitePlus
S273 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y275 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S276 Phosphorylation PhosphoSitePlus
S281 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
T283 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
S314 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18220336, 15144186, 18691976, 18669648
T317 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S327 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S329 Phosphorylation PhosphoSitePlus
S335 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S336 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S337 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
Y369 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
Y390 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 24275569
S395 Phosphorylation PhosphoSitePlus
S403 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S406 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 15144186, ...18220336
T412 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 15144186, 16094384
T419 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
S422 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y425 Phosphorylation PhosphoSitePlus
S427 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T432 Phosphorylation PhosphoSitePlus
S438 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T440 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
Y478 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 12522270
Y482 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
Y487 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus
S510 Phosphorylation phospho.ELM   PhosphoSitePlus 15572359
S512 Phosphorylation phospho.ELM   PhosphoSitePlus 15572359
S515 Phosphorylation phospho.ELM   PhosphoSitePlus 15572359
K518 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K625 Acetylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
S776 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 20068231, 24275569, ...17081983
S778 Phosphorylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
S891 Phosphorylation PhosphoSitePlus
T894 Phosphorylation PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
K954 Ubiquitination PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
K982 Methylation PhosphoSitePlus
T990 Phosphorylation PhosphoSitePlus
Y1001 Phosphorylation PhosphoSitePlus
T1013 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
T1017 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1048 Phosphorylation phospho.ELM 15572359
S1049 Phosphorylation phospho.ELM 15572359
Y1062 Phosphorylation PhosphoSitePlus
Y1071 Phosphorylation PhosphoSitePlus
Y1084 Phosphorylation PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus
S1091 Phosphorylation PhosphoSitePlus
Y1094 Phosphorylation PhosphoSitePlus
S1097 Phosphorylation PhosphoSitePlus
Y1098 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
Y1115 Phosphorylation PhosphoSitePlus
Y1116 Phosphorylation PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
S1121 Phosphorylation PhosphoSitePlus
K1124 Ubiquitination PhosphoSitePlus
Y1129 Phosphorylation PhosphoSitePlus
Y1132 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
S1138 Phosphorylation PhosphoSitePlus
Y1139 Phosphorylation PhosphoSitePlus
Y1143 Phosphorylation PhosphoSitePlus
S1153 Phosphorylation PhosphoSitePlus
T1154 Phosphorylation PhosphoSitePlus
Y1156 Phosphorylation PhosphoSitePlus
S1157 Phosphorylation PhosphoSitePlus
T1158 Phosphorylation PhosphoSitePlus
Y1160 Phosphorylation PhosphoSitePlus
T1166 Phosphorylation PhosphoSitePlus
Y1168 Phosphorylation PhosphoSitePlus
Y1172 Phosphorylation PhosphoSitePlus
K1175 Ubiquitination PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
Y1179 Phosphorylation PhosphoSitePlus
S1187 Phosphorylation PhosphoSitePlus
S1190 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation HPRD 19413330, 19691289
S221 Phosphorylation HPRD 19413330, 20068231
S227 Phosphorylation HPRD 20068231
S231 Phosphorylation HPRD 20068231
S233 Phosphorylation HPRD 19413330, 20068231
S273 Phosphorylation HPRD 18669648, 15144186
Y275 Phosphorylation HPRD 15144186
S276 Phosphorylation HPRD 15144186
S281 Phosphorylation HPRD 18669648, 19691289, 15144186
S314 Phosphorylation HPRD 19413330, 19664994, 19664995, ...15144186, 19691289, 18669648
S327 Phosphorylation HPRD 19413330, 18669648, 20068231
S335 Phosphorylation HPRD 18669648, 20068231
S336 Phosphorylation HPRD 19413330, 18669648, 19691289, ...20068231
S337 Phosphorylation HPRD 19413330, 18578522, 18669648, ...20068231, 19664995
Y372 Phosphorylation HPRD 17389395
Y390 Phosphorylation HPRD 16094384
S392 Phosphorylation HPRD 17525332
S403 Phosphorylation HPRD 18669648
S406 Phosphorylation HPRD 18669648, 15144186
Y415 Phosphorylation HPRD 19901323, 15144186
Y420 Phosphorylation HPRD 19901323
Y421 Phosphorylation HPRD 15144186
S422 Phosphorylation HPRD 18669648
S427 Phosphorylation HPRD 18669648
S438 Phosphorylation HPRD 17525332
S447 Phosphorylation HPRD 19691289
Y470 Phosphorylation HPRD 16497976
Y478 Phosphorylation HPRD 12522270, 16497976
Y482 Phosphorylation HPRD 12522270, 16497976
Y487 Phosphorylation HPRD 16497976
S512 Phosphorylation HPRD 20068231
S515 Phosphorylation HPRD 20068231
S776 Phosphorylation HPRD 18578522, 17081983, 20068231, ...18452278
S778 Phosphorylation HPRD 17081983
Y1168 Phosphorylation HPRD 17389395
Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation HPRD 19413330, 19691289
Y157 Phosphorylation PhosphoSitePlus
S221 Phosphorylation HPRD 19413330, 20068231
S227 Phosphorylation HPRD 20068231
S231 Phosphorylation HPRD 20068231
S233 Phosphorylation HPRD 19413330, 20068231
Y261 Phosphorylation PhosphoSitePlus
S273 Phosphorylation HPRD 18669648, 15144186
Y275 Phosphorylation HPRD 15144186
S276 Phosphorylation HPRD 15144186
S281 Phosphorylation HPRD 18669648, 19691289, 15144186
Y306 Phosphorylation PhosphoSitePlus
S314 Phosphorylation HPRD 19413330, 19664994, 19664995, ...15144186, 19691289, 18669648
S327 Phosphorylation HPRD 19413330, 18669648, 20068231
S335 Phosphorylation HPRD 18669648, 20068231
S336 Phosphorylation HPRD 19413330, 18669648, 19691289, ...20068231
S337 Phosphorylation HPRD 19413330, 18578522, 18669648, ...20068231, 19664995
Y369 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation HPRD   PhosphoSitePlus 17389395
Y390 Phosphorylation HPRD 16094384
S392 Phosphorylation HPRD 17525332
S403 Phosphorylation HPRD 18669648
S406 Phosphorylation HPRD 18669648, 15144186
Y415 Phosphorylation HPRD   PhosphoSitePlus 19901323, 15144186
Y420 Phosphorylation HPRD   PhosphoSitePlus 19901323
Y421 Phosphorylation HPRD   PhosphoSitePlus 15144186
S422 Phosphorylation HPRD 18669648
Y425 Phosphorylation PhosphoSitePlus
S427 Phosphorylation HPRD 18669648
S438 Phosphorylation HPRD 17525332
S447 Phosphorylation HPRD 19691289
Y470 Phosphorylation HPRD   PhosphoSitePlus 16497976
Y478 Phosphorylation HPRD   PhosphoSitePlus 12522270, 16497976
Y482 Phosphorylation HPRD   PhosphoSitePlus 12522270, 16497976
Y487 Phosphorylation HPRD   PhosphoSitePlus 16497976
Y494 Phosphorylation PhosphoSitePlus
S512 Phosphorylation HPRD 20068231
S515 Phosphorylation HPRD 20068231
S776 Phosphorylation HPRD 18578522, 17081983, 20068231, ...18452278
S778 Phosphorylation HPRD 17081983
S1037 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
Y1051 Phosphorylation PhosphoSitePlus
Y1055 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
Y1072 Phosphorylation PhosphoSitePlus
Y1073 Phosphorylation PhosphoSitePlus
Y1100 Phosphorylation PhosphoSitePlus
Y1113 Phosphorylation PhosphoSitePlus
Y1125 Phosphorylation HPRD   PhosphoSitePlus 17389395
Y1129 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S82 R82 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S132 A132 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S136 C136 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S136 R136 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S179 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R207 Q207 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R211 K211 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S214 L214 Biomuta DOID:363 / uterine cancer [ tcga ]
S221 F221 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S223 Y223 Biomuta DOID:363 / uterine cancer [ tcga ]
Y224 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R254 Q254 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S259 I259 Biomuta DOID:3571 / liver cancer [ icgc ]
R270 W270 Biomuta DOID:363 / uterine cancer [ tcga ]
S281 A281 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S297 Y297 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S314 F314 Biomuta DOID:363 / uterine cancer [ tcga ]
T319 M319 Biomuta DOID:1115 / sarcoma [ tcga ]
S335 L335 Biomuta DOID:363 / uterine cancer [ tcga ]
S337 P337 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ]
S389 F389 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y390 F390 Biomuta DOID:1324 / lung cancer [ cosmic ]
T412 A412 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y415 H415 Biomuta DOID:2596 / larynx cancer [ cosmic ]
S422 I422 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y425 C425 Biomuta DOID:363 / uterine cancer [ tcga ]
T440 M440 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:2531 / hematologic cancer [ icgc ]
S457 F457 Biomuta DOID:3070 / malignant glioma [ icgc ]
S457 C457 Biomuta DOID:1324 / lung cancer [ cosmic ]
K573 R573 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S776 P776 Biomuta DOID:363 / uterine cancer [ tcga ]
S812 L812 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S812 W812 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S812 P812 Biomuta DOID:3070 / malignant glioma [ tcga ]
S891 F891 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y1071 C1071 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y1084 D1084 Biomuta DOID:5041 / esophageal cancer [ tcga ]
Y1132 C1132 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S1153 C1153 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y1160 C1160 Biomuta DOID:1909 / melanoma [ cosmic ]
K1175 E1175 Biomuta DOID:4159 / skin cancer [ icgc ]