iPTMnet Report for Q99558 (MAP3K14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99558 / M3K14_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 14
Gene Name Name: MAP3K14
Synonyms:NIK;
Organism Homo sapiens (Human)

PRO ID PR:Q99558
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 14 (human)
Definition A mitogen-activated protein kinase kinase kinase 14 that is encoded in the genome of human.
Short Label hMAP3K14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99558 (MAP3K14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
Y40 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
C533 Methylation IEDB 31844290
T559 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11278268, 21700900, 20501937, ...23301098, 20682767, 26269411, 9742107
T559 Phosphorylation O15111 (CHUK) Signor 20501937
T559 Phosphorylation P41279 (MAP3K8) HPRD   Signor 11278268, 9742107
C573 Methylation IEDB 31844290
S643 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
S694 Phosphorylation IEDB 27920218
S814 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus


Q99558 (MAP3K14) as PTM Enzyme



Substrate Site Score Source PMID
O14920-1 (IKBKB) S177 HPRD   PhosphoSitePlus 10195894, 10022904, 9689078, ...10779355
O14920-1 (IKBKB) S181 HPRD   PhosphoSitePlus 10195894, 10022904, 9689078, ...10779355
O15111 (CHUK) S176 HPRD   neXtProt   PhosphoSitePlus   Signor 10195894, 9819420, 16286467, ...9520446
O15111 (CHUK) S180 HPRD   PhosphoSitePlus   Signor 10195894, 9819420, 16286467, ...9520446
P25963 (NFKBIA) S32 PhosphoSitePlus 9707608
P25963 (NFKBIA) S36 PhosphoSitePlus 9707608
P61160 (ACTR2) Y202 PhosphoSitePlus 25601402
P61160 (ACTR2) T237 PhosphoSitePlus 25601402
P61160 (ACTR2) T238 PhosphoSitePlus 25601402
Q00653-4 (NFKB2) S865 HPRD 11239468
Q00653 (NFKB2) S866 phospho.ELM   PhosphoSitePlus   Signor 11239468
Q00653-4 (NFKB2) S869 HPRD 11239468
Q00653 (NFKB2) S870 phospho.ELM   PhosphoSitePlus   Signor 11239468


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048304 (hMAP3K14/Phos:1) pT559 PRO
PR:000048305 (hMAP3K14/PhosRes+) p PRO
PR:000048306 (hMAP3K14/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 E47 Biomuta DOID:3571 / liver cancer [ cosmic ]
K106 T106 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K198 N198 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K211 M211 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S410 F410 Biomuta DOID:4159 / skin cancer [ cosmic ]
S694 L694 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S817 Y817 Biomuta DOID:363 / uterine cancer [ cosmic ]
S820 L820 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]