iPTMnet Report for Q99549 (MPHOSPH8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99549 / MPP8_HUMAN
Protein Name M-phase phosphoprotein 8
Gene Name Name: MPHOSPH8
Synonyms:MPP8;
Organism Homo sapiens (Human)

PRO ID PR:Q99549
DAG View
PRO Name M-phase phosphoprotein 8 (human)
Definition An M-phase phosphoprotein 8 that is encoded in the genome of human.
Short Label hMPHOSPH8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99549 (MPHOSPH8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
S16 Phosphorylation PhosphoSitePlus
S20 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T21 Phosphorylation phospho.ELM 18669648
S51 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 18669648, 24275569, 19690332, 20068231
K73 Acetylation PhosphoSitePlus
Y83 Phosphorylation RLIMS-P 21419134
T84 Phosphorylation PhosphoSitePlus   RLIMS-P 21419134
S85 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 21419134, 18669648, 17081983
S126 Phosphorylation PhosphoSitePlus
S136 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S138 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S142 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T144 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S149 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23416073, 18669648, 19690332
K163 Acetylation PhosphoSitePlus
S164 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23416073, 17081983
K169 Acetylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus   UniProt 19690332
S189 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S192 Phosphorylation PhosphoSitePlus   UniProt 19690332
S204 Phosphorylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus   UniProt 24275569
S279 Phosphorylation PhosphoSitePlus   UniProt 24275569
S284 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
T334 Phosphorylation PhosphoSitePlus   UniProt 23416073
S369 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus   UniProt 23416073
K387 Ubiquitination PhosphoSitePlus
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S400 Phosphorylation PhosphoSitePlus   UniProt 20068231
T401 Phosphorylation PhosphoSitePlus
S403 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
T410 Phosphorylation PhosphoSitePlus
K436 Methylation PhosphoSitePlus
K439 Acetylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
T454 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K458 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
Y716 Phosphorylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
T841 Phosphorylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 18669648
T21 Phosphorylation HPRD 18669648
S51 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19664995, 18452278, 19651622, 18669648, 20068231, 19691289
Y83 Phosphorylation HPRD 17081983
T84 Phosphorylation HPRD 17081983, 20068231
S85 Phosphorylation HPRD 18669648, 17081983
S136 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S138 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S142 Phosphorylation HPRD 18669648, 17081983
T144 Phosphorylation HPRD 18669648, 17081983
S149 Phosphorylation HPRD 18669648
S164 Phosphorylation HPRD 17081983, 20068231
S188 Phosphorylation HPRD 19651622, 20068231
S189 Phosphorylation HPRD 18669648
S319 Phosphorylation HPRD 19651622, 17081983, 18452278
T358 Phosphorylation HPRD 20068231
S392 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S400 Phosphorylation HPRD 20068231
T401 Phosphorylation HPRD 20068231
S403 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
T454 Phosphorylation HPRD 18669648, 20068231
T841 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 N20 Biomuta DOID:363 / uterine cancer [ icgc ]
S85 L85 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S136 Y136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
K169 N169 Biomuta DOID:363 / uterine cancer [ icgc ]
K170 N170 Biomuta DOID:1324 / lung cancer [ cosmic ]
S204 Y204 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S264 Y264 Biomuta DOID:363 / uterine cancer [ icgc ]
S316 N316 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T385 M385 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T401 M401 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T500 M500 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]