iPTMnet Report for Q99538 (LGMN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99538 / LGMN_HUMAN
Protein Name Legumain precursor
Gene Name Name: LGMN
Synonyms:PRSC1;
Organism Homo sapiens (Human)

PRO ID PR:Q99538
DAG View
PRO Name legumain (human)
Definition A legumain that is encoded in the genome of human.
Short Label hLGMN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99538 (LGMN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 O-Glycosylation GlyGen 23301498, 34019948, 29351928
C50 S-Nitrosylation dbSNO 26338901
N91 N-Glycosylation GlyGen   UniProt 23776206, 19159218
K125 Ubiquitination PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
N167 N-Glycosylation GlyGen   UniProt 23776206, 19159218, 24190977, ...23090970, 32125861, 29741879
Y185 Phosphorylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
N263 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 23776206, ...24190977
N272 N-Glycosylation GlyGen   UniProt 23090970, 23776206, 24190977
T274 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
K287 Acetylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
T305 O-Glycosylation GlyGen 26598643
S307 O-Glycosylation GlyGen 26598643
K316 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K342 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C50 Y50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K125 T125 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S226 P226 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N263 S263 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S307 N307 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T322 N322 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K342 T342 Biomuta DOID:9256 / colorectal cancer [ cosmic ]