iPTMnet Report for Q99523 (SORT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99523 / SORT_HUMAN
Protein Name Sortilin precursor
Gene Name Name: SORT1
Organism Homo sapiens (Human)

PRO ID PR:Q99523
DAG View
PRO Name sortilin (human)
Definition A sortilin that is encoded in the genome of human.
Short Label hSORT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99523 (SORT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N98 N-Glycosylation GlyGen 23090970, 29741879, 32125861, ...24190977
N99 N-Glycosylation GlyGen 24190977
N162 N-Glycosylation GlyGen   UniProt 16263699, 23090970, 24190977, ...29741879, 19349973
N163 N-Glycosylation GlyGen 24190977
K248 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
N274 N-Glycosylation GlyGen 29741879, 24190977
K294 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
N406 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19122660, ...24190977
N582 N-Glycosylation GlyGen   UniProt 19122660
N684 N-Glycosylation GlyGen 24190977
S793 Phosphorylation PhosphoSitePlus   RLIMS-P 24986865
S814 Phosphorylation PhosphoSitePlus   UniProt 23186163
S819 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y821 Phosphorylation PhosphoSitePlus
S825 Phosphorylation P67870 (CSNK2B) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 25805502, 23186163, ...18669648, 18088087
Site PTM Type PTM Enzyme Score Source PMID
N162 N-Glycosylation PRO 29741879
T168 Phosphorylation HPRD 20068231
T185 Phosphorylation HPRD 20068231
T298 Phosphorylation HPRD 20068231
S305 Phosphorylation HPRD 20068231
N406 N-Glycosylation PRO 29741879
S819 Phosphorylation HPRD 19651622, 20068231
S825 Phosphorylation HPRD 19651622, 18669648, 18088087, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S305 L305 Biomuta DOID:4159 / skin cancer [ cosmic ]
S814 F814 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S825 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]