Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99504 / EYA3_HUMAN
Protein Name Eyes absent homolog 3
Gene Name Name: EYA3
Organism Homo sapiens (Human)

PRO ID PR:Q99504
DAG View
PRO Name eyes absent homolog 3 (human)
Definition An eyes absent homolog 3 that is encoded in the genome of human.
Short Label hEYA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99504 (EYA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
M1 Acetylation UniProt 19413330
K37 Sumoylation PhosphoSitePlus
S63 O-Glycosylation GlyGen 23301498, 32119511, 30059200, ...29351928
Y67 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
Y72 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
Y77 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
S86 O-Glycosylation GlyGen 23301498, 32119511, 30059200, ...29351928
T88 O-Glycosylation GlyGen 23301498, 32119511, 30059200, ...29351928
Y90 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
Y96 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183, 29440662
Y105 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183, 29440662
Y108 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
Y115 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183, 29440662
S225 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183, 29440662
S255 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus   UniProt 23186163
S264 Phosphorylation PhosphoSitePlus
S266 Phosphorylation Q13315 (ATM) , P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 19234442, 17525332, 18847512
T268 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T269 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S271 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T274 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
K430 Methylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus   UniProt 23186163
S472 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y496 Phosphorylation RLIMS-P 29440662
Y508 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
K515 Ubiquitination PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
Y532 Phosphorylation PhosphoSitePlus   RLIMS-P 31847183
K546 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S264 Phosphorylation HPRD 18077418
S266 Phosphorylation HPRD 18077418
S438 Phosphorylation HPRD 19651622, 19664994


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047343 (hEYA3/PhosSer+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S63 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S86 T86 Biomuta DOID:3070 / malignant glioma [ tcga ]
S86 L86 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S138 Y138 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S255 F255 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S256 C256 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
T295 N295 Biomuta DOID:3571 / liver cancer [ icgc ]
K430 T430 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S472 C472 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]