iPTMnet Report for Q99496 (RNF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99496 / RING2_HUMAN
Protein Name E3 ubiquitin-protein ligase RING2
Gene Name Name: RNF2
Synonyms:BAP1,DING,HIPI3,RING1B;
Organism Homo sapiens (Human)

PRO ID PR:Q99496
DAG View
PRO Name E3 ubiquitin-protein ligase RING2 (human)
Definition An E3 ubiquitin-protein ligase RING2 that is encoded in the genome of human.
Short Label hRNF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99496 (RNF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus   UniProt 25519132
K65 Ubiquitination PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 23186163
K149 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus   UniProt 23186163, 25519132
S200 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
T250 O-Glycosylation GlyGen 26100231
S251 O-Glycosylation GlyGen 26100231
S260 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S278 O-Glycosylation GlyGen 23301498, 20305658, 33214551, ...34019948, 26100231
K323 Sumoylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19007248, 19691289
S143 Phosphorylation HPRD 20068231
S168 Phosphorylation HPRD 19413330, 17081983
S203 Phosphorylation HPRD 19007248


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y120 H120 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S143 R143 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K249 T249 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S251 F251 Biomuta DOID:4159 / skin cancer [ cosmic ]
S260 F260 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K261 E261 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]