iPTMnet Report for Q99490 (AGAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99490 / AGAP2_HUMAN
Protein Name Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Gene Name Name: AGAP2
Synonyms:CENTG1,KIAA0167;
Organism Homo sapiens (Human)

PRO ID PR:Q99490
DAG View
PRO Name Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (human)
Definition An Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 that is encoded in the genome of human.
Short Label hAGAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99490 (AGAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
R3 Methylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
S279 Phosphorylation RLIMS-P   Signor 18487454
S279 Phosphorylation Q00535 (CDK5) Signor 18487454
Y431 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
R505 Methylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
Y544 Phosphorylation PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus   UniProt 19690332
T647 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
F682 Phosphorylation UniProt 16841086
K685 Methylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
P774 Phosphorylation UniProt 16841086
S808 Phosphorylation PhosphoSitePlus
T809 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus
S827 O-Glycosylation GlyGen 30379171, 30620550
S827 Phosphorylation PhosphoSitePlus
K831 Acetylation PhosphoSitePlus
K832 Acetylation PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus
S985 Phosphorylation Signor 19176382
S985 Phosphorylation P31749 (AKT1) Signor 19176382
T1006 Phosphorylation PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
Y1038 Phosphorylation Signor 16841086
Y1038 Phosphorylation P06241 (FYN) Signor 16841086
Y1130 Phosphorylation Signor 16841086
Y1130 Phosphorylation P06241 (FYN) Signor 16841086
T1170 Phosphorylation PhosphoSitePlus
S1172 Phosphorylation PhosphoSitePlus
S1177 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
S1181 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S249 Phosphorylation neXtProt   PhosphoSitePlus 18487454
S249 Phosphorylation Q00535 (CDK5) PhosphoSitePlus 18487454
S279 Phosphorylation neXtProt   PhosphoSitePlus 18487454
S279 Phosphorylation Q00535 (CDK5) PhosphoSitePlus 18487454
S312 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus 21460185
S472 Phosphorylation P31749 (AKT1) PhosphoSitePlus 21460185
K495 Acetylation PhosphoSitePlus
K496 Acetylation PhosphoSitePlus
S629 Phosphorylation neXtProt   PhosphoSitePlus 19176382
S629 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 19176382
Y682 Phosphorylation neXtProt   PhosphoSitePlus 16841086
Y682 Phosphorylation P06241 (FYN) neXtProt   PhosphoSitePlus 16841086
Y774 Phosphorylation neXtProt   PhosphoSitePlus 16841086
Y774 Phosphorylation P06241 (FYN) neXtProt   PhosphoSitePlus 16841086


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35240 (NF2) S315 Q99490 (AGAP2) inhibited_association eFIP 19262146


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S249 P249 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S629 L629 Biomuta DOID:4159 / skin cancer [ cosmic ]