iPTMnet Report for Q99459 (CDC5L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99459 / CDC5L_HUMAN
Protein Name Cell division cycle 5-like protein
Gene Name Name: CDC5L
Synonyms:KIAA0432,PCDC5RP;
Organism Homo sapiens (Human)

PRO ID PR:Q99459
DAG View
PRO Name cell division cycle 5-like protein (human)
Definition A cell division cycle 5-like protein that is encoded in the genome of human.
Short Label hCDC5L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99459 (CDC5L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
K41 Methylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
C96 Methylation IEDB 31844290
K165 Methylation PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
K219 Sumoylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
T227 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18583928
S228 Phosphorylation PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
R252 Methylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S303 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18583928, 18452278, 18669648, 20068231
S317 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T344 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus   UniProt 18583928
T373 O-Glycosylation GlyGen 33214551, 32522876, 29351928, ...34019948, 32119511, 28510447, 34229054
T373 Phosphorylation PhosphoSitePlus
T377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
K380 Ubiquitination PhosphoSitePlus
T385 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18583928, 18669648, 14729942, 19690332, 20068231
S390 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664994, 17081983, ...18220336
S393 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 18220336
T396 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 19664994, 18452278, 18669648, 24275569, 14729942, 19690332, 20068231
T404 Phosphorylation PhosphoSitePlus   UniProt 18583928
T407 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus 18847512
S410 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T411 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18583928, 18847512
T411 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T415 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S417 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18583928
T424 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18583928, ...18669648, 20068231
S427 Phosphorylation PhosphoSitePlus
T429 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T430 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
K432 Ubiquitination PhosphoSitePlus
S437 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18220336
T438 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 18583928, ...18220336
T442 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
K447 Ubiquitination PhosphoSitePlus
Y459 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
Y621 Phosphorylation PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K626 Acetylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
Y788 Phosphorylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
T797 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S253 F253 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S273 F273 Biomuta DOID:4159 / skin cancer [ cosmic ]
S417 C417 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T442 S442 Biomuta DOID:1319 / brain cancer [ cosmic ]
S460 N460 Biomuta DOID:1319 / brain cancer [ icgc ]
K487 R487 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K487 N487 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S691 L691 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K694 M694 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]