iPTMnet Report for Q99439 (CNN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99439 / CNN2_HUMAN
Protein Name Calponin-2
Gene Name Name: CNN2
Organism Homo sapiens (Human)

PRO ID PR:Q99439
DAG View
PRO Name calponin-2 (human)
Definition A calponin-2 that is encoded in the genome of human.
Short Label hCNN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99439 (CNN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
K8 Acetylation PhosphoSitePlus   UniProt 19608861
K8 Methylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
Y12 Phosphorylation PhosphoSitePlus 18698806
Y12 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
S15 Phosphorylation PhosphoSitePlus
K19 Sumoylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K25 Acetylation PhosphoSitePlus   UniProt 19608861
K25 Ubiquitination PhosphoSitePlus
Y26 Phosphorylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
C61 S-Nitrosylation dbSNO 20140087, 22178444
K66 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus   UniProt 23186163
K145 Ubiquitination PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
K160 Methylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
C164 Methylation IEDB 31844290
C164 S-Nitrosylation dbSNO 20140087, 22178444
T172 Phosphorylation PhosphoSitePlus
K174 Methylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T186 Phosphorylation PhosphoSitePlus
R187 Methylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
C215 S-Nitrosylation dbSNO 2212679, 22126794
S217 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
K234 Sumoylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
N242 N-Glycosylation GlyGen 24190977
S243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S246 O-Glycosylation GlyGen 23301498, 27655845, 36580660, ...34725712, 34019948, 35132862, 28510447
S246 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
T252 O-Glycosylation GlyGen 23301498, 27655845, 36580660, ...34725712, 34019948, 35132862, 28510447
T252 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T172 Phosphorylation HPRD 18212344
Y184 Phosphorylation HPRD 18083107
Y303 Phosphorylation HPRD 15592455
Site PTM Type PTM Enzyme Score Source PMID
Y145 Phosphorylation HPRD 18083107
Y264 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 L11 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T42 S42 Biomuta DOID:4159 / skin cancer [ cosmic ]
K194 N194 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S217 N217 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T222 A222 Biomuta DOID:1319 / brain cancer [ icgc ]
Y231 C231 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K234 R234 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K234 E234 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y302 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]