iPTMnet Report Q99259 GAD1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q99259 / DCE1_HUMAN
Protein Name	Glutamate decarboxylase 1
Gene Name	Name: GAD1 Synonyms:GAD,GAD67;
Organism	Homo sapiens (Human)

PRO ID	PR:Q99259 DAG View
PRO Name	glutamate decarboxylase 1 (human)
Definition	A glutamate decarboxylase 1 that is encoded in the genome of human.
Short Label	hGAD1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q99259 (GAD1) as Substrate

Expanded View

Search:

	Site Select all By amino acid All Serine All Threonine All Tyrosine By position K60 K68 K74 T91 Y265 S571 S578	PTM Type Select all Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 3	Source Select all PhosphoSitePlus RLIMS-P neXtProt	PMID
	K60	Ubiquitination		score1	PhosphoSitePlus
	K68	Ubiquitination		score1	PhosphoSitePlus
	K74	Ubiquitination		score1	PhosphoSitePlus
	T91	Phosphorylation	P17612 (PRKACA)	score3	neXtProt PhosphoSitePlus RLIMS-P	15147202
	Y265	Phosphorylation		score1	PhosphoSitePlus
	S571	Phosphorylation		score1	PhosphoSitePlus
	S578	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Serine All Threonine By position T91 S571	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1	Source Select all HPRD	PMID
	T91	Phosphorylation	Q02156 (PRKCE)	score1	HPRD	15147202
	S571	Phosphorylation		score0	HPRD	18452278

Search:

	Site Select all By amino acid All Threonine By position T91	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
	T91	Phosphorylation	Q02156 (PRKCE)	score1	HPRD	15147202

PTM sites affected in variants

Search:

Site Select all By amino acid All Tyrosine By position K60 K74 Y265	Variant Select all C265 N60 N74	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K60	N60	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
K74	N74	Biomuta		DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y265	C265	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]