iPTMnet Report for Q99250 (SCN2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99250 / SCN2A_HUMAN
Protein Name Sodium channel protein type 2 subunit alpha
Gene Name Name: SCN2A
Synonyms:NAC2,SCN2A1,SCN2A2;
Organism Homo sapiens (Human)

PRO ID PR:Q99250
DAG View
PRO Name sodium channel protein type 2 subunit alpha (human)
Definition A sodium channel protein type 2 subunit alpha that is encoded in the genome of human.
Short Label hSCN2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99250 (SCN2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N340 N-Glycosylation GlyGen   UniProt 30765605
S491 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
T699 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S1112 Phosphorylation neXtProt 19064667
S1124 Phosphorylation neXtProt 19064667
S1126 Phosphorylation neXtProt 19064667
N1368 N-Glycosylation GlyGen   UniProt 30765605
N1382 N-Glycosylation GlyGen   UniProt 30765605
N1393 N-Glycosylation GlyGen   UniProt 30765605
K1496 Acetylation PhosphoSitePlus
Y1674 Phosphorylation PhosphoSitePlus
Y1684 Phosphorylation PhosphoSitePlus
S1889 Phosphorylation PhosphoSitePlus
Y1893 Phosphorylation PhosphoSitePlus
T1897 Phosphorylation PhosphoSitePlus
T1898 Phosphorylation PhosphoSitePlus
T1899 Phosphorylation PhosphoSitePlus
Y1919 Phosphorylation PhosphoSitePlus
K1938 Ubiquitination PhosphoSitePlus
K1946 Ubiquitination PhosphoSitePlus
K1953 Ubiquitination PhosphoSitePlus
S1971 Phosphorylation PhosphoSitePlus
S1974 Phosphorylation PhosphoSitePlus
K1990 Methylation PhosphoSitePlus
K1998 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S497 N497 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S497 R497 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S540 F540 Biomuta DOID:4159 / skin cancer [ cosmic ]
S554 F554 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S610 Y610 Biomuta DOID:363 / uterine cancer [ icgc ]
S700 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S700 L700 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1112 A1112 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1889 Y1889 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1893 D1893 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1897 M1897 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S1974 L1974 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]