iPTMnet Report for Q99075 (HBEGF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99075 / HBEGF_HUMAN
Protein Name Proheparin-binding EGF-like growth factor precursor
Gene Name Name: HBEGF
Synonyms:DTR,DTS,HEGFL;
Organism Homo sapiens (Human)

PRO ID PR:Q99075
DAG View
PRO Name proheparin-binding EGF-like growth factor (human)
Definition A proheparin-binding EGF-like growth factor that is encoded in the genome of human.
Short Label hHBEGF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99075 (HBEGF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
T37 O-Glycosylation GlyGen   UniProt 30459171, 23234360
T37 Phosphorylation PhosphoSitePlus
S38 O-Glycosylation GlyGen   UniProt 23234360
S38 Phosphorylation PhosphoSitePlus
T44 O-Glycosylation GlyGen   UniProt 30459171, 23234360, 22171320, ...30237853
T44 Phosphorylation PhosphoSitePlus
S46 O-Glycosylation GlyGen 30237853
T47 O-Glycosylation GlyGen   UniProt 30459171, 30237853, 22171320
T75 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 11769972, 1556128, 25813380, ...23584533
S77 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S78 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T85 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 11769972, 25813380, 23584533, ...1556128
K95 Acetylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   RLIMS-P 16557002


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S38 G38 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T44 I44 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S78 P78 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K95 N95 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S207 F207 Biomuta DOID:4159 / skin cancer [ cosmic ]