iPTMnet Report for Q96TA2 (YME1L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96TA2 / YMEL1_HUMAN
Protein Name ATP-dependent zinc metalloprotease YME1L1
Gene Name Name: YME1L1
Synonyms:FTSH1,YME1L;ORFNames:UNQ1868/PRO4304;
Organism Homo sapiens (Human)

PRO ID PR:Q96TA2
DAG View
PRO Name ATP-dependent zinc metalloprotease YME1L1 (human)
Definition An ATP-dependent zinc metalloprotease YME1L1 that is encoded in the genome of human.
Short Label hYME1L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96TA2 (YME1L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S109 O-Glycosylation GlyGen 33465208
S111 O-Glycosylation GlyGen 33465208
S115 O-Glycosylation GlyGen 28510447, 33465208
S155 O-Glycosylation GlyGen 33465208
S161 O-Glycosylation GlyGen 28510447, 33465208
C180 Methylation IEDB 31844290
S220 O-Glycosylation GlyGen 33465208
S220 Phosphorylation IEDB   PhosphoSitePlus 35260532, 32387766
T221 Phosphorylation PhosphoSitePlus
S222 O-Glycosylation GlyGen 28510447, 33465208
K237 Acetylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
T566 O-Glycosylation GlyGen 28510447, 33465208
K568 Ubiquitination PhosphoSitePlus
N592 N-Glycosylation GlyGen 23090970, 24190977
K691 Ubiquitination PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T270 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T213 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S109 F109 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S161 F161 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
T221 I221 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S315 F315 Biomuta DOID:4159 / skin cancer [ cosmic ]
S315 T315 Biomuta DOID:4159 / skin cancer [ cosmic ]
K363 T363 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K446 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K568 R568 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S704 N704 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]