Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96T51 / RUFY1_HUMAN
Protein Name RUN and FYVE domain-containing protein 1
Gene Name Name: RUFY1
Synonyms:RABIP4,ZFYVE12;
Organism Homo sapiens (Human)

PRO ID PR:Q96T51
DAG View
PRO Name RUN and FYVE domain-containing protein 1 (human)
Definition A RUN and FYVE domain-containing protein 1 that is encoded in the genome of human.
Short Label hRUFY1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96T51 (RUFY1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R12 Methylation PhosphoSitePlus
R14 Methylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
C184 S-Nitrosylation dbSNO 2212679, 22126794
S188 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
K225 Methylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
C320 S-Nitrosylation dbSNO 26338901
K338 Ubiquitination PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
R349 Methylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
Y389 Phosphorylation P51813 (BMX) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 11877430
K390 Ubiquitination PhosphoSitePlus
Y400 Phosphorylation P51813 (BMX) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 11877430
S401 Phosphorylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K555 Methylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
S618 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S620 Phosphorylation PhosphoSitePlus   UniProt 24275569
K621 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S618 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S510 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K164 E164 Biomuta DOID:10534 / stomach cancer [ icgc ]
K164 N164 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
C184 F184 Biomuta DOID:3571 / liver cancer [ icgc ]
S344 L344 Biomuta DOID:4362 / cervical cancer [ tcga ]
S344 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R349 L349 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S352 A352 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y389 C389 Biomuta DOID:363 / uterine cancer [ tcga ]
K490 N490 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]