iPTMnet Report for Q96SZ6 (CDK5RAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96SZ6 / CK5P1_HUMAN
Protein Name Mitochondrial tRNA methylthiotransferase CDK5RAP1 precursor
Gene Name Name: CDK5RAP1
Synonyms:C20orf34;ORFNames:CGI-05,HSPC167;
Organism Homo sapiens (Human)

PRO ID PR:Q96SZ6
DAG View
PRO Name mitochondrial tRNA methylthiotransferase CDK5RAP1 (human)
Definition A mitochondrial tRNA methylthiotransferase CDK5RAP1 that is encoded in the genome of human.
Short Label hCDK5RAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96SZ6 (CDK5RAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
R298 Methylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K546 Acetylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K198 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 C37 Biomuta DOID:1324 / lung cancer [ cosmic ]
K189 N189 Biomuta DOID:363 / uterine cancer [ icgc ]
K198 R198 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T583 A583 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]