Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96ST3 / SIN3A_HUMAN
Protein Name Paired amphipathic helix protein Sin3a
Gene Name Name: SIN3A
Organism Homo sapiens (Human)

PRO ID PR:Q96ST3
DAG View
PRO Name paired amphipathic helix protein Sin3a (human)
Definition A paired amphipathic helix protein Sin3a that is encoded in the genome of human.
Short Label hSIN3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96ST3 (SIN3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19413330, ...18452278, 19651622, 18669648, 20068231
Y13 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S251 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
T260 Phosphorylation PhosphoSitePlus
S263 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
T266 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S277 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20058876
T284 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
T284 Phosphorylation PhosphoSitePlus
T287 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
S289 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
S289 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T292 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
S295 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
Y310 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
T434 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
T435 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 20068230
S450 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K469 Acetylation PhosphoSitePlus   UniProt 19608861
S505 Phosphorylation PhosphoSitePlus
Y524 Phosphorylation PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
C551 S-Nitrosylation dbSNO 26338901
Y558 Phosphorylation PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
Y565 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus
K601 Acetylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
Y610 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K723 Acetylation PhosphoSitePlus
K727 Acetylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K737 Methylation PhosphoSitePlus
S746 Phosphorylation HPRD   phospho.ELM 18669648
K747 Ubiquitination PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus
Y757 Phosphorylation PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
S832 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...19664994, 19664995, 18452278, 19651622, 18669648, 19690332, 20166139, 15345747, 19415658, 20068231
S860 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 15302935, ...19651622, 20068231
K865 Acetylation PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
K875 Acetylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
K934 Acetylation PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
K937 Ubiquitination PhosphoSitePlus
S938 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S940 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19691289, 18452278, ...18669648, 20068231
Y958 Phosphorylation PhosphoSitePlus
Y959 Phosphorylation PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
S1089 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1101 Phosphorylation PhosphoSitePlus
Y1105 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation HPRD   PhosphoSitePlus 19413330
T1110 Phosphorylation HPRD   PhosphoSitePlus 19664995
T1111 Phosphorylation HPRD   PhosphoSitePlus 19664995
S1112 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 23186163, ...15302935, 19664994, 19664995, 19691289, 19651622, 18669648, 19690332, 19415658, 20068231
K1122 Ubiquitination PhosphoSitePlus
K1154 Ubiquitination PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus
K1164 Ubiquitination PhosphoSitePlus
K1170 Acetylation PhosphoSitePlus
K1170 Ubiquitination PhosphoSitePlus
Y1178 Phosphorylation HPRD 20068231
K1219 Ubiquitination PhosphoSitePlus
S1231 O-Glycosylation GlyGen 23301498, 30059200, 29351928, ...12150998, 32119511, 28510447, 22661428
S1231 Phosphorylation PhosphoSitePlus
K1232 Ubiquitination PhosphoSitePlus
K1271 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 L10 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S23 N23 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S169 P169 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T284 K284 Biomuta DOID:3571 / liver cancer [ icgc ]
T292 M292 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S295 Y295 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1115 / sarcoma [ tcga ]
T432 I432 Biomuta DOID:1324 / lung cancer [ tcga ]
S505 C505 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y524 F524 Biomuta DOID:3571 / liver cancer [ tcga ]
Y558 C558 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K563 N563 Biomuta DOID:1324 / lung cancer [ cosmic ]
K601 R601 Biomuta DOID:2531 / hematologic cancer [ tcga ]
Y610 C610 Biomuta DOID:3277 / thymus cancer [ tcga ]
K650 N650 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K697 * Biomuta DOID:1324 / lung cancer [ tcga ]
S746 Y746 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S748 G748 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S832 L832 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S860 N860 Biomuta DOID:0070003 / blastoma [ cosmic ]
S940 I940 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
Y959 C959 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S1089 L1089 Biomuta DOID:363 / uterine cancer [ tcga ]
T1111 A1111 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1112 L1112 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1112 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y1178 C1178 Biomuta DOID:5041 / esophageal cancer [ tcga ]