iPTMnet Report for Q96ST2 (IWS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96ST2 / IWS1_HUMAN
Protein Name Protein IWS1 homolog
Gene Name Name: IWS1
Synonyms:IWS1L;
Organism Homo sapiens (Human)

PRO ID PR:Q96ST2
DAG View
PRO Name protein IWS1 homolog (human)
Definition A protein IWS1 that is encoded in the genome of human.
Short Label hIWS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96ST2 (IWS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S7 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T67 Phosphorylation PhosphoSitePlus
S69 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S80 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983, 16565220
S82 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983, 16565220
S84 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S93 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S157 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S159 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S167 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus   UniProt 24275569
S196 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 24275569
S198 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 24275569
S209 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
S235 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569, 20068231
S237 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569, 20068231
S248 O-Glycosylation GlyGen 28411811, 36580660, 30379171, ...34019948, 28510447, 33465208
S248 Phosphorylation PhosphoSitePlus   UniProt 23186163
S250 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S252 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569, 20068231
S263 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569, 20068231
S274 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243
S276 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...24275569
S278 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S287 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 19690332
S289 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569
S300 Phosphorylation PhosphoSitePlus   UniProt 21406692
S302 Phosphorylation PhosphoSitePlus   UniProt 21406692
S304 Phosphorylation PhosphoSitePlus   UniProt 21406692
S313 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 20068231, 16964243
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243, 18669648, 19690332, ...20068231, 17081983
T317 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
S329 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983
S333 O-Glycosylation GlyGen 28411811, 36580660, 30379171, ...34019948, 28510447, 33465208
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
T342 Phosphorylation PhosphoSitePlus
S348 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S351 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus   UniProt 20068231
S365 Phosphorylation PhosphoSitePlus   UniProt 20068231
S377 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19367720, 18669648, 20068231
S398 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...16964243, 15302935, 18318008, 18669648, 24275569, 17287340, 19690332, 17081983
S400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...16964243, 18318008, 18669648, 24275569, 17287340, 19690332, 20068231, 17081983
S407 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16964243
K409 Acetylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
S415 O-Glycosylation GlyGen 28411811, 36580660, 30379171, ...34019948, 28510447, 33465208
S415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 20068231
S420 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 20068231, ...24275569
S422 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S426 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S429 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K434 Acetylation PhosphoSitePlus
T435 O-Glycosylation GlyGen 33465208
T435 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S438 O-Glycosylation GlyGen 28411811, 36580660, 30379171, ...34019948, 28510447, 33465208
S438 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 16964243, ...18669648, 24275569, 23186163, 20068231, 17081983
S440 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 24275569, 17287340, 19690332, 20068231, 17081983
S449 Phosphorylation PhosphoSitePlus
S461 Phosphorylation UniProt 29997176
S463 Phosphorylation UniProt 29997176
S465 Phosphorylation UniProt 29997176
S480 Phosphorylation PhosphoSitePlus   UniProt 29997176, 24275569
T489 Phosphorylation UniProt 29997176
S511 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
S513 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
K518 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
T589 Phosphorylation PhosphoSitePlus
K600 Acetylation PhosphoSitePlus
K604 Acetylation PhosphoSitePlus
S610 O-Glycosylation GlyGen 28411811, 36580660, 30379171, ...34019948, 28510447, 33465208
S621 Phosphorylation PhosphoSitePlus
R626 Methylation PhosphoSitePlus
S720 Phosphorylation Q9Y243 (AKT3) PhosphoSitePlus   Signor 24462114
T721 Phosphorylation Q9Y243 (AKT3) PhosphoSitePlus   Signor 24462114
T725 Phosphorylation PhosphoSitePlus   UniProt 23186163
C749 Methylation IEDB 31844290
Y762 Phosphorylation PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
K783 Methylation PhosphoSitePlus
K794 Methylation PhosphoSitePlus
K816 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 18452278
S11 Phosphorylation HPRD 18452278
T17 Phosphorylation HPRD 19651622
T53 Phosphorylation HPRD 19651622
S54 Phosphorylation HPRD 20068231, 18452278
T67 Phosphorylation HPRD 17081983, 18452278
S69 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S80 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S82 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S84 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S95 Phosphorylation HPRD 15302935
S108 Phosphorylation HPRD 16565220
S122 Phosphorylation HPRD 18452278
S131 Phosphorylation HPRD 17081983
S133 Phosphorylation HPRD 16565220, 18452278
S144 Phosphorylation HPRD 17081983, 18452278
S146 Phosphorylation HPRD 16565220, 18452278
S157 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 18452278
S159 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 18452278
S167 Phosphorylation HPRD 17081983
S170 Phosphorylation HPRD 19413330, 15302935
S172 Phosphorylation HPRD 19413330, 17081983
T174 Phosphorylation HPRD 17081983
S183 Phosphorylation HPRD 15302935
S185 Phosphorylation HPRD 15302935
S187 Phosphorylation HPRD 17081983
S196 Phosphorylation HPRD 19651622, 16565220
S198 Phosphorylation HPRD 19651622, 16565220
S209 Phosphorylation HPRD 18452278
S211 Phosphorylation HPRD 18452278
S213 Phosphorylation HPRD 18452278
S222 Phosphorylation HPRD 15302935, 18452278
S224 Phosphorylation HPRD 15302935, 18452278
S235 Phosphorylation HPRD 16565220
S237 Phosphorylation HPRD 16565220
S248 Phosphorylation HPRD 19651622, 17081983
S250 Phosphorylation HPRD 19651622, 17081983
S261 Phosphorylation HPRD 19651622, 16565220, 18452278
S263 Phosphorylation HPRD 19651622, 16565220
S274 Phosphorylation HPRD 19651622
S276 Phosphorylation HPRD 19651622, 18669648
S278 Phosphorylation HPRD 18669648
S287 Phosphorylation HPRD 19651622, 18669648, 16565220, ...15302935, 18452278
S289 Phosphorylation HPRD 19651622, 18669648, 16565220, ...15302935, 18452278
S300 Phosphorylation HPRD 19413330, 19651622
S302 Phosphorylation HPRD 19413330, 19651622
S304 Phosphorylation HPRD 19413330, 19651622
S313 Phosphorylation HPRD 19413330, 16964243, 19651622, ...18669648, 20068231, 17081983
S315 Phosphorylation HPRD 19413330, 16964243, 15302935, ...19651622, 18669648, 20068231
T317 Phosphorylation HPRD 19651622
S329 Phosphorylation HPRD 19651622, 17081983, 20068231
S333 Phosphorylation HPRD 19651622, 17081983, 20068231
T342 Phosphorylation HPRD 17081983
S348 Phosphorylation HPRD 17081983
S353 Phosphorylation HPRD 17081983
S362 Phosphorylation HPRD 19651622, 17081983, 20068231
S363 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231
S365 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231
S377 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S398 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 18767875, 18452278, 19651622, 18669648, 19415658, 20068231
S400 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 18767875, 19691289, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S407 Phosphorylation HPRD 18669648, 16964243
S415 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S420 Phosphorylation HPRD 19651622, 18767875, 18669648, ...17081983, 20068231
S422 Phosphorylation HPRD 18767875, 15302935, 18452278, ...19651622, 18669648, 20068231
S426 Phosphorylation HPRD 19651622, 18669648, 15302935, ...18452278
S429 Phosphorylation HPRD 18669648
T435 Phosphorylation HPRD 19413330, 20166139, 18669648
S438 Phosphorylation HPRD 19413330, 17287340, 16964243, ...15302935, 19691289, 19651622, 18669648, 20166139, 19415658, 20068231
S440 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S461 Phosphorylation HPRD 17081983
S463 Phosphorylation HPRD 17081983
S465 Phosphorylation HPRD 17081983
S480 Phosphorylation HPRD 17081983
S511 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S513 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S720 Phosphorylation HPRD 20166139, 19664995, 18707149
T721 Phosphorylation HPRD 19664995
T725 Phosphorylation HPRD 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T17 A17 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S84 R84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S120 Y120 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S122 I122 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S159 F159 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S159 C159 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S159 Y159 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S172 Y172 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S263 L263 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ]
S276 L276 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S300 R300 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S304 T304 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S329 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S348 Y348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S353 I353 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S429 L429 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S429 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K434 N434 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S438 F438 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K600 T600 Biomuta DOID:1319 / brain cancer [ icgc ]
S621 L621 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R626 K626 Biomuta DOID:4159 / skin cancer [ cosmic ]