iPTMnet Report for Q96SN8 (CDK5RAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96SN8 / CK5P2_HUMAN
Protein Name CDK5 regulatory subunit-associated protein 2
Gene Name Name: CDK5RAP2
Synonyms:CEP215,KIAA1633;
Organism Homo sapiens (Human)

PRO ID PR:Q96SN8
DAG View
PRO Name CDK5 regulatory subunit-associated protein 2 (human)
Definition A CDK5 regulatory subunit-associated protein 2 that is encoded in the genome of human.
Short Label hCDK5RAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96SN8 (CDK5RAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K61 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
T102 Phosphorylation Q38SD2 (LRRK1) PhosphoSitePlus 26192437
K114 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S140 Phosphorylation Q38SD2 (LRRK1) PhosphoSitePlus   RLIMS-P 26192437
K152 Ubiquitination PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
C239 Methylation IEDB 31844290
K241 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K431 Sumoylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
S547 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S548 Phosphorylation PhosphoSitePlus
Y550 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
Y564 Phosphorylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K656 Acetylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K665 Acetylation PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
C683 Methylation IEDB 31844290
S697 Phosphorylation PhosphoSitePlus
T698 Phosphorylation PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
S815 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K822 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K859 Ubiquitination PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
K886 Ubiquitination PhosphoSitePlus
K897 Ubiquitination PhosphoSitePlus
K943 Ubiquitination PhosphoSitePlus
S945 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
Y952 Phosphorylation PhosphoSitePlus
K983 Ubiquitination PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus   UniProt 20068231
K1004 Ubiquitination PhosphoSitePlus
T1005 Phosphorylation PhosphoSitePlus
Y1017 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
S1074 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16565220
T1076 Phosphorylation PhosphoSitePlus
S1077 Phosphorylation PhosphoSitePlus
K1085 Ubiquitination PhosphoSitePlus
K1091 Ubiquitination PhosphoSitePlus
S1102 Phosphorylation PhosphoSitePlus
Y1111 Phosphorylation PhosphoSitePlus
K1113 Ubiquitination PhosphoSitePlus
K1159 Ubiquitination PhosphoSitePlus
K1161 Ubiquitination PhosphoSitePlus
S1164 Phosphorylation PhosphoSitePlus
S1172 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
K1184 Ubiquitination PhosphoSitePlus
K1203 Ubiquitination PhosphoSitePlus
K1212 Ubiquitination PhosphoSitePlus
K1215 Ubiquitination PhosphoSitePlus
K1233 Ubiquitination PhosphoSitePlus
S1238 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...16565220
S1244 Phosphorylation PhosphoSitePlus
K1261 Ubiquitination PhosphoSitePlus
K1320 Ubiquitination PhosphoSitePlus
Y1343 Phosphorylation PhosphoSitePlus
S1350 Phosphorylation PhosphoSitePlus
S1354 Phosphorylation PhosphoSitePlus
S1360 Phosphorylation PhosphoSitePlus
Y1362 Phosphorylation PhosphoSitePlus
K1367 Ubiquitination PhosphoSitePlus
S1368 Phosphorylation PhosphoSitePlus
S1389 Phosphorylation PhosphoSitePlus
S1428 Phosphorylation PhosphoSitePlus
K1457 Ubiquitination PhosphoSitePlus
K1468 Ubiquitination PhosphoSitePlus
K1487 Ubiquitination PhosphoSitePlus
T1488 Phosphorylation PhosphoSitePlus
S1490 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1541 Ubiquitination PhosphoSitePlus
S1548 Phosphorylation PhosphoSitePlus
S1556 Phosphorylation PhosphoSitePlus
K1562 Ubiquitination PhosphoSitePlus
K1566 Ubiquitination PhosphoSitePlus
S1617 Phosphorylation PhosphoSitePlus
K1620 Ubiquitination PhosphoSitePlus
S1666 Phosphorylation PhosphoSitePlus
C1708 Methylation IEDB 31844290
K1722 Ubiquitination PhosphoSitePlus
K1769 Ubiquitination PhosphoSitePlus
K1778 Ubiquitination PhosphoSitePlus
K1798 Ubiquitination PhosphoSitePlus
K1822 Ubiquitination PhosphoSitePlus
K1827 Ubiquitination PhosphoSitePlus
K1844 Ubiquitination PhosphoSitePlus
K1865 Ubiquitination PhosphoSitePlus
T1885 Phosphorylation PhosphoSitePlus
S1887 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1889 Phosphorylation PhosphoSitePlus
S1893 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
T324 Phosphorylation HPRD 20068231
Y461 Phosphorylation HPRD 17924679
S466 Phosphorylation HPRD 17924679
S468 Phosphorylation HPRD 17924679
S547 Phosphorylation HPRD 19651622, 18669648, 20068231
S815 Phosphorylation HPRD 16565220
S904 Phosphorylation HPRD 20068231
T1001 Phosphorylation HPRD 20068231
S1074 Phosphorylation HPRD 18669648, 20068231, 16565220
S1083 Phosphorylation HPRD 20068231
S1102 Phosphorylation HPRD 19007248
S1238 Phosphorylation HPRD 18669648, 19691289, 16565220
S1483 Phosphorylation HPRD 19007248
T1488 Phosphorylation HPRD 18452278
S1490 Phosphorylation HPRD 18452278
S1548 Phosphorylation HPRD 17081983
S1556 Phosphorylation HPRD 17081983
S1887 Phosphorylation HPRD 18669648
S1893 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K705 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T324 Phosphorylation HPRD 20068231
Y461 Phosphorylation HPRD 17924679
S466 Phosphorylation HPRD 17924679
S468 Phosphorylation HPRD 17924679
S547 Phosphorylation HPRD 19651622, 18669648, 20068231
S815 Phosphorylation HPRD 16565220
S904 Phosphorylation HPRD 20068231
T1001 Phosphorylation HPRD 20068231
S1074 Phosphorylation HPRD 18669648, 20068231, 16565220
S1083 Phosphorylation HPRD 20068231
S1102 Phosphorylation HPRD 19007248
S1238 Phosphorylation HPRD 18669648, 19691289, 16565220
S1483 Phosphorylation HPRD 19007248
T1488 Phosphorylation HPRD 18452278
S1490 Phosphorylation HPRD 18452278
S1548 Phosphorylation HPRD 17081983
S1556 Phosphorylation HPRD 17081983
S1808 Phosphorylation HPRD 18669648
S1814 Phosphorylation HPRD 18669648


Q96SN8 (CDK5RAP2) as PTM Enzyme



Substrate Site Score Source PMID
P05067 (APP) T743 Signor 15178331


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K71 N71 Biomuta DOID:263 / kidney cancer [ cosmic ]
K126 R126 Biomuta DOID:263 / kidney cancer [ cosmic ]
K198 T198 Biomuta DOID:363 / uterine cancer [ icgc ]
T360 A360 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T371 A371 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S374 L374 Biomuta DOID:4159 / skin cancer [ cosmic ]
S391 C391 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S400 I400 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K403 N403 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y461 C461 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K462 T462 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K462 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K471 T471 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y550 D550 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S613 N613 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K656 N656 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S697 P697 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S706 I706 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S815 F815 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K865 R865 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S904 N904 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y952 H952 Biomuta DOID:1319 / brain cancer [ icgc ]
Y952 C952 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K983 R983 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T1005 M1005 Biomuta DOID:363 / uterine cancer [ icgc ]
K1028 Q1028 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1037 R1037 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1061 N1061 Biomuta DOID:4362 / cervical cancer [ icgc ]
S1077 A1077 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1077 L1077 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
K1091 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1161 N1161 Biomuta DOID:363 / uterine cancer [ icgc ]
K1161 E1161 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1368 F1368 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1548 L1548 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1617 N1617 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
C1708 W1708 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1814 F1814 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1893 F1893 Biomuta DOID:1324 / lung cancer [ cosmic ]