iPTMnet Report for Q96SB8 (SMC6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96SB8 / SMC6_HUMAN
Protein Name Structural maintenance of chromosomes protein 6
Gene Name Name: SMC6
Synonyms:SMC6L1;
Organism Homo sapiens (Human)

PRO ID PR:Q96SB8
DAG View
PRO Name structural maintenance of chromosomes protein 6 (human)
Definition A structural maintenance of chromosomes protein 6 that is encoded in the genome of human.
Short Label hSMC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96SB8 (SMC6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
C58 Methylation IEDB 31844290
K107 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S158 O-Glycosylation GlyGen 30379171
S158 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S165 O-Glycosylation GlyGen 30379171
S165 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
C251 Methylation IEDB 31844290
S260 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K694 Ubiquitination PhosphoSitePlus
K773 Sumoylation PhosphoSitePlus
Y780 Phosphorylation PhosphoSitePlus
K784 Acetylation PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
K786 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
T828 Phosphorylation PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
Y902 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
K917 Ubiquitination PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
K978 Ubiquitination PhosphoSitePlus
K1035 Ubiquitination PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
T1083 Phosphorylation PhosphoSitePlus
R1091 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T1083 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T166 M166 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K798 E798 Biomuta DOID:363 / uterine cancer [ icgc ]
T828 A828 Biomuta DOID:4362 / cervical cancer [ icgc ]
K831 E831 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K831 I831 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y902 * Biomuta DOID:263 / kidney cancer [ cosmic ]