iPTMnet Report for Q96S66 (CLCC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96S66 / CLCC1_HUMAN
Protein Name Chloride channel CLIC-like protein 1 precursor
Gene Name Name: CLCC1
Synonyms:KIAA0761,MCLC;
Organism Homo sapiens (Human)

PRO ID PR:Q96S66
DAG View
PRO Name chloride channel CLIC-like protein 1 (human)
Definition A chloride channel CLIC-like protein 1 that is encoded in the genome of human.
Short Label hCLCC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96S66 (CLCC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S42 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K324 Acetylation PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
T407 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
Y412 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S438 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 17924679
R443 Methylation PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S464 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T469 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K470 Ubiquitination PhosphoSitePlus
T474 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T482 O-Glycosylation GlyGen 25813380
T482 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S503 Phosphorylation PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
S509 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
K518 Ubiquitination PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S524 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S529 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
S532 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S547 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
C550 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S438 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231, 17924679
S461 Phosphorylation HPRD 20068231
S464 Phosphorylation HPRD 18669648, 20068231
T474 Phosphorylation HPRD 20068231
T482 Phosphorylation HPRD 18691976, 20068231
T506 Phosphorylation HPRD 20068231
S509 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994
S524 Phosphorylation HPRD 19413330, 18669648, 20068231
Y531 Phosphorylation HPRD 19413330
S532 Phosphorylation HPRD 18669648, 19664994, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S388 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231, 17924679
S411 Phosphorylation HPRD 20068231
S414 Phosphorylation HPRD 18669648, 20068231
T424 Phosphorylation HPRD 20068231
T432 Phosphorylation HPRD 18691976, 20068231
T456 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994
S474 Phosphorylation HPRD 19413330, 18669648, 20068231
Y481 Phosphorylation HPRD 19413330
S482 Phosphorylation HPRD 18669648, 19664994, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S411 I411 Biomuta DOID:363 / uterine cancer [ icgc ]
S414 P414 Biomuta DOID:3571 / liver cancer [ cosmic ]
S414 L414 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R443 L443 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R443 W443 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T456 I456 Biomuta DOID:1324 / lung cancer [ cosmic ]
S461 I461 Biomuta DOID:363 / uterine cancer [ icgc ]
S464 P464 Biomuta DOID:3571 / liver cancer [ cosmic ]
S464 L464 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S482 N482 Biomuta DOID:1319 / brain cancer [ cosmic ]
S503 L503 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T506 I506 Biomuta DOID:1324 / lung cancer [ cosmic ]
S532 N532 Biomuta DOID:1319 / brain cancer [ cosmic ]