iPTMnet Report Q96S53 TESK2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q96S53 / TESK2_HUMAN
Protein Name	Dual specificity testis-specific protein kinase 2
Gene Name	Name: TESK2
Organism	Homo sapiens (Human)

PRO ID	PR:Q96S53 DAG View
PRO Name	dual specificity testis-specific protein kinase 2 (human)
Definition	A dual specificity testis-specific protein kinase 2 that is encoded in the genome of human.
Short Label	hTESK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q96S53 (TESK2) as Substrate

Q96S53

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S8	Phosphorylation		score1	PhosphoSitePlus
	K180	Ubiquitination		score1	PhosphoSitePlus
	K326	Ubiquitination		score1	PhosphoSitePlus
	S346	Phosphorylation		score1	PhosphoSitePlus
	S367	Phosphorylation		score1	PhosphoSitePlus
	S369	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
	S381	Phosphorylation		score1	PhosphoSitePlus
	K412	Ubiquitination		score1	PhosphoSitePlus
	S456	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
	S460	Phosphorylation		score1	PhosphoSitePlus
	S477	Phosphorylation		score1	PhosphoSitePlus
	S488	Phosphorylation		score1	PhosphoSitePlus

Q96S53 (TESK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P23528 (CFL1)	S3	score4	HPRD phospho.ELM Signor	11340065, 19413330, 18578522, ...18491316, 18702456, 9655398, 20058876, 19651622, 18669648, 11925442, 11418599, 20068231
	P60981 (DSTN)	S3	score3	HPRD Signor	19413330, 19651622, 11418599, ...20068231
	Q9Y281 (CFL2)	S3	score1	Signor	11418599

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S8	L8	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S381	T381	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]