iPTMnet Report for Q96RU2 (USP28)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RU2 / UBP28_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 28
Gene Name Name: USP28
Synonyms:KIAA1515;
Organism Homo sapiens (Human)

PRO ID PR:Q96RU2
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 28 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 28 that is encoded in the genome of human.
Short Label hUSP28
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RU2 (USP28) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S67 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 16901786, 31938050
S67 Phosphorylation Q13315 (ATM) PhosphoSitePlus 16901786
T70 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K99 Sumoylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus   UniProt 23186163
K381 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
Y447 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus   RLIMS-P 17478428, 31938050
S495 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S503 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
Y654 Phosphorylation PhosphoSitePlus
S714 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17478428, 17525332, 16901786, ...31938050
S714 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428, 16901786
S720 Phosphorylation PhosphoSitePlus 17478428
S720 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
T753 Phosphorylation PhosphoSitePlus
T788 Phosphorylation PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus
K897 Ubiquitination PhosphoSitePlus
Y901 Phosphorylation PhosphoSitePlus
C986 Methylation IEDB 31844290
T1048 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1053 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 17525332
S131 Phosphorylation HPRD 20068231
S714 Phosphorylation HPRD 17525332


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96RU2 (USP28) S67 O95198 (KLHL2) inhibited_association eFIP 31938050


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S113 F113 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K381 Q381 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K420 N420 Biomuta DOID:363 / uterine cancer [ icgc ]
Y654 F654 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S714 P714 Biomuta DOID:363 / uterine cancer [ icgc ]
S714 L714 Biomuta DOID:4159 / skin cancer [ cosmic ]
K839 E839 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1053 Y1053 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]