iPTMnet Report for Q96RT1 (ERBIN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RT1 / ERBIN_HUMAN
Protein Name Erbin
Gene Name Name: ERBIN
Synonyms:ERBB2IP;
Organism Homo sapiens (Human)

PRO ID PR:Q96RT1
DAG View
PRO Name erbin (human)
Definition An erbin that is encoded in the genome of human.
Short Label hERBIN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RT1 (ERBIN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K46 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S440 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S444 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S448 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y487 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K506 Sumoylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
Y552 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S569 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S572 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S598 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S602 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17081983, 20068231
S603 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17081983, 20068231
S620 Phosphorylation PhosphoSitePlus   UniProt 23186163
S630 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
S714 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S715 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T716 Phosphorylation phospho.ELM 18669648
K719 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
Y733 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
K769 Ubiquitination PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
Y813 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus   UniProt 24275569
T853 Phosphorylation PhosphoSitePlus
S857 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
K860 Ubiquitination PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T874 Phosphorylation PhosphoSitePlus
Y884 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
K914 Ubiquitination PhosphoSitePlus
S915 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T917 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 15144186
Y920 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
T928 Phosphorylation PhosphoSitePlus
S930 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S931 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S932 Phosphorylation PhosphoSitePlus
S933 Phosphorylation PhosphoSitePlus
S934 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K945 Ubiquitination PhosphoSitePlus
Y972 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
Y977 Phosphorylation PhosphoSitePlus
Y981 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S982 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
S994 Phosphorylation PhosphoSitePlus
S1013 O-Glycosylation GlyGen 30379171, 31492838, 34019948, ...35289036, 35254053
S1015 Phosphorylation PhosphoSitePlus
Y1021 Phosphorylation PhosphoSitePlus
K1023 Ubiquitination PhosphoSitePlus
T1040 Phosphorylation PhosphoSitePlus
Y1042 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1070 O-Glycosylation GlyGen   IEDB 30379171, 31492838, 35254053, ...34019948, 26280087, 35289036
T1073 Phosphorylation PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
S1079 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus 18669648, 32357974
S1081 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1085 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1093 Phosphorylation PhosphoSitePlus
T1094 Phosphorylation PhosphoSitePlus
Y1104 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 15144186, 16094384
S1106 Phosphorylation PhosphoSitePlus
Y1107 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T1116 Phosphorylation PhosphoSitePlus
Y1132 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S1133 Phosphorylation PhosphoSitePlus
S1144 Phosphorylation PhosphoSitePlus
S1148 Phosphorylation PhosphoSitePlus
T1156 Phosphorylation PhosphoSitePlus
S1158 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S1160 Phosphorylation PhosphoSitePlus
Y1164 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
T1167 Phosphorylation PhosphoSitePlus
S1170 Phosphorylation PhosphoSitePlus
S1179 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1182 Phosphorylation PhosphoSitePlus
Y1235 Phosphorylation PhosphoSitePlus
Y1270 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S1286 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y1293 Phosphorylation PhosphoSitePlus
Y1304 Phosphorylation PhosphoSitePlus
T1305 Phosphorylation PhosphoSitePlus
S1310 Phosphorylation PhosphoSitePlus
K1319 Ubiquitination PhosphoSitePlus
K1367 Ubiquitination PhosphoSitePlus
Y1381 Phosphorylation PhosphoSitePlus
S1382 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S440 Phosphorylation HPRD 19651622, 18669648, 18452278
S444 Phosphorylation HPRD 19651622
Y483 Phosphorylation HPRD 17924679
T485 Phosphorylation HPRD 18212344, 17924679
Y487 Phosphorylation HPRD 17924679
S569 Phosphorylation HPRD 18669648, 20068231
S572 Phosphorylation HPRD 18669648
S602 Phosphorylation HPRD 19651622, 18088087, 20068231
S603 Phosphorylation HPRD 19651622, 18088087, 20068231
S714 Phosphorylation HPRD 18669648
S715 Phosphorylation HPRD 18669648, 20068231
T716 Phosphorylation HPRD 18669648
Y733 Phosphorylation HPRD 15592455
S852 Phosphorylation HPRD 19651622
S857 Phosphorylation HPRD 18669648, 15302935
S872 Phosphorylation HPRD 18212344
S915 Phosphorylation HPRD 18669648, 15570572
T917 Phosphorylation HPRD 18669648, 15144186
Y920 Phosphorylation HPRD 17016520, 15144186
S930 Phosphorylation HPRD 18669648
S931 Phosphorylation HPRD 18669648
S934 Phosphorylation HPRD 18669648
Y972 Phosphorylation HPRD 15570572
Y977 Phosphorylation HPRD 15592455
Y981 Phosphorylation HPRD 15592455
S1060 Phosphorylation HPRD 18669648, 20068231
S1078 Phosphorylation HPRD 20068231
S1079 Phosphorylation HPRD 18669648, 20068231
S1081 Phosphorylation HPRD 20068231
S1082 Phosphorylation HPRD 18669648, 20068231
T1083 Phosphorylation HPRD 20068231
S1085 Phosphorylation HPRD 18669648
S1093 Phosphorylation HPRD 20068231
T1094 Phosphorylation HPRD 20068231
Y1104 Phosphorylation HPRD 17016520, 19901323, 17389395, ...15144186
Y1107 Phosphorylation HPRD 15592455
S1158 Phosphorylation HPRD 18212344
Y1164 Phosphorylation HPRD 19901323
Site PTM Type PTM Enzyme Score Source PMID
S440 Phosphorylation HPRD 19651622, 18669648, 18452278
S444 Phosphorylation HPRD 19651622
Y483 Phosphorylation HPRD 17924679
T485 Phosphorylation HPRD 18212344, 17924679
Y487 Phosphorylation HPRD 17924679
S569 Phosphorylation HPRD 18669648, 20068231
S572 Phosphorylation HPRD 18669648
S602 Phosphorylation HPRD 19651622, 18088087, 20068231
S603 Phosphorylation HPRD 19651622, 18088087, 20068231
S714 Phosphorylation HPRD 18669648
S715 Phosphorylation HPRD 18669648, 20068231
T716 Phosphorylation HPRD 18669648
Y733 Phosphorylation HPRD 15592455
S852 Phosphorylation HPRD 19651622
S857 Phosphorylation HPRD 18669648, 15302935
S872 Phosphorylation HPRD 18212344
S915 Phosphorylation HPRD 18669648, 15570572
T917 Phosphorylation HPRD 18669648, 15144186
Y920 Phosphorylation HPRD 17016520, 15144186
S930 Phosphorylation HPRD 18669648
S931 Phosphorylation HPRD 18669648
S934 Phosphorylation HPRD 18669648
Y972 Phosphorylation HPRD 15570572
Y977 Phosphorylation HPRD 15592455
Y981 Phosphorylation HPRD 15592455
S1060 Phosphorylation HPRD 18669648, 20068231
S1078 Phosphorylation HPRD 20068231
S1079 Phosphorylation HPRD 18669648, 20068231
S1081 Phosphorylation HPRD 20068231
S1082 Phosphorylation HPRD 18669648, 20068231
T1083 Phosphorylation HPRD 20068231
S1085 Phosphorylation HPRD 18669648
S1093 Phosphorylation HPRD 20068231
T1094 Phosphorylation HPRD 20068231
Y1104 Phosphorylation HPRD 17016520, 19901323, 17389395, ...15144186
Y1107 Phosphorylation HPRD 15592455
S1158 Phosphorylation HPRD 18212344
Y1164 Phosphorylation HPRD 19901323
Site PTM Type PTM Enzyme Score Source PMID
S1217 Phosphorylation PhosphoSitePlus
S1239 Phosphorylation PhosphoSitePlus
S1242 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation PhosphoSitePlus
S1253 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K73 T73 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K371 Q371 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K381 N381 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S444 G444 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S444 R444 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S569 T569 Biomuta DOID:3571 / liver cancer [ cosmic ]
S572 G572 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S603 F603 Biomuta DOID:4159 / skin cancer [ cosmic ]
S620 F620 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S715 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S715 L715 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
S818 F818 Biomuta DOID:4159 / skin cancer [ cosmic ]
S841 I841 Biomuta DOID:363 / uterine cancer [ icgc ]
S841 N841 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S844 F844 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S857 F857 Biomuta DOID:1324 / lung cancer [ cosmic ]
S870 Y870 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K914 R914 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T928 I928 Biomuta DOID:4159 / skin cancer [ cosmic ]
S931 P931 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S933 P933 Biomuta DOID:363 / uterine cancer [ icgc ]
S934 F934 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y977 C977 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S994 C994 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1015 I1015 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T1070 I1070 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1083 P1083 Biomuta DOID:4606 / bile duct cancer [ cosmic, cosmic ] DOID:3571 / liver cancer [ cosmic, cosmic, icgc, cosmic, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc, cosmic, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc, cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:263 / kidney cancer [ cosmic, icgc, cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, cosmic ]
S1093 C1093 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T1116 S1116 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1133 N1133 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1156 N1156 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1160 R1160 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y1164 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S1239 R1239 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1293 F1293 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y1293 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K1367 T1367 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]