Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RR4 / KKCC2_HUMAN
Protein Name Calcium/calmodulin-dependent protein kinase kinase 2
Gene Name Name: CAMKK2
Synonyms:CAMKKB,KIAA0787;
Organism Homo sapiens (Human)

PRO ID PR:Q96RR4
DAG View
PRO Name calcium/calmodulin-dependent protein kinase kinase 2 (human)
Definition A calcium/calmodulin-dependent protein kinase kinase 2 that is encoded in the genome of human.
Short Label hCAMKK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RR4 (CAMKK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
K32 Ubiquitination PhosphoSitePlus
T85 Phosphorylation Q96RR4 (CAMKK2) PhosphoSitePlus   RLIMS-P 26395653, 28230171
S95 Phosphorylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 23186163
S125 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
S129 Phosphorylation Q00535 (CDK5) , P49841 (GSK3B) , P49840 (GSK3A) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26395653, 18669648, 23186163, ...22778263
S132 Phosphorylation PhosphoSitePlus
S133 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) , Q00535 (CDK5) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26395653, 28230171, 18669648, ...22778263
S136 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S137 Phosphorylation P49841 (GSK3B) , Q00535 (CDK5) , P49840 (GSK3A) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21669867, 28230171, 22778263
T145 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
T483 Phosphorylation Q96RR4 (CAMKK2) neXtProt   Signor 9822657, 21859090, 22778263, ...21957496
K488 Ubiquitination PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 24275569
S509 Phosphorylation PhosphoSitePlus
S511 Phosphorylation P53355 (DAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15209507, 23186163, 29914450
S572 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y128 Phosphorylation HPRD 18691976
S129 Phosphorylation HPRD 18669648
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD 18691976, 18669648
S136 Phosphorylation HPRD 18669648
S495 Phosphorylation HPRD 18691976, 19664994, 20058876
S509 Phosphorylation HPRD 20058876
S511 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y128 Phosphorylation HPRD 18691976
S129 Phosphorylation HPRD 18669648
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD 18691976, 18669648
S136 Phosphorylation HPRD 18669648
S495 Phosphorylation HPRD 18691976, 19664994, 20058876
S509 Phosphorylation HPRD 20058876
S511 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y128 Phosphorylation HPRD 18691976
S129 Phosphorylation HPRD   PhosphoSitePlus 18669648
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
S136 Phosphorylation HPRD   PhosphoSitePlus 18669648
S495 Phosphorylation HPRD 18691976, 19664994, 20058876
S509 Phosphorylation HPRD 20058876
S511 Phosphorylation HPRD   PhosphoSitePlus 18691976
K519 Ubiquitination PhosphoSitePlus
S522 Phosphorylation HPRD   PhosphoSitePlus 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y128 Phosphorylation HPRD 18691976
S129 Phosphorylation HPRD 18669648
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD 18691976, 18669648
S136 Phosphorylation HPRD 18669648
K441 Ubiquitination PhosphoSitePlus
S452 Phosphorylation HPRD 18691976, 19664994, 20058876
S466 Phosphorylation HPRD 20058876
S468 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y128 Phosphorylation HPRD 18691976
S129 Phosphorylation HPRD 18669648
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD 18691976, 18669648
S136 Phosphorylation HPRD 18669648
K441 Ubiquitination PhosphoSitePlus
S452 Phosphorylation HPRD 18691976, 19664994, 20058876
S466 Phosphorylation HPRD 20058876
S468 Phosphorylation HPRD 18691976
S479 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y128 Phosphorylation HPRD 18691976
S129 Phosphorylation HPRD 18669648
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD 18691976, 18669648
S136 Phosphorylation HPRD 18669648
K441 Ubiquitination PhosphoSitePlus
S452 Phosphorylation HPRD 18691976, 19664994, 20058876
S466 Phosphorylation HPRD 20058876
S468 Phosphorylation HPRD 18691976


Q96RR4 (CAMKK2) as PTM Enzyme



Substrate Site Score Source PMID
P54646 (PRKAA2) T172 Signor 15980064, 19958286
Q13131 (PRKAA1) T183 neXtProt   PhosphoSitePlus   Signor 23583109, 15980064, 21918180, ...23625915
Q14012 (CAMK1) T177 HPRD   neXtProt 9822657, 23110126, 11395482
Q16566 (CAMK4) T200 HPRD   neXtProt 9822657, 21957496
Q8IU85 (CAMK1D) T180 neXtProt 12935886
Q96EB6 (SIRT1) S27 neXtProt 23754392
Q96EB6 (SIRT1) S47 neXtProt 23754392
Q96RR4 (CAMKK2) T85 PhosphoSitePlus 26395653
Q96RR4 (CAMKK2) T483 neXtProt   Signor 9822657, 21859090, 22778263, ...21957496


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T85 S85 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T85 I85 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S114 N114 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
Y183 S183 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y234 H234 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K314 Q314 Biomuta DOID:1612 / breast cancer [ tcga ]
T350 M350 Biomuta DOID:5041 / esophageal cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S509 L509 Biomuta DOID:1909 / melanoma [ icgc, tcga ]