iPTMnet Report for Q96RQ3 (MCCC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RQ3 / MCCA_HUMAN
Protein Name Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor
Gene Name Name: MCCC1
Synonyms:MCCA;
Organism Homo sapiens (Human)

PRO ID PR:Q96RQ3
DAG View
PRO Name methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (human)
Definition A methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial that is encoded in the genome of human. The human MCCC1 gene contains 19 exons, and maps to the chromosomal location 3q25-27.
Short Label hMCCC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RQ3 (MCCC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
Y270 Phosphorylation IEDB 35494241
K295 Acetylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
T418 O-Glycosylation GlyGen 33214551, 34725712, 35083852, ...34019948, 29351928
K518 Ubiquitination PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
T550 Phosphorylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S220 P220 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S220 L220 Biomuta DOID:4159 / skin cancer [ cosmic ]
K248 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K295 T295 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S535 F535 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S724 L724 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]