iPTMnet Report for Q96RN5 (MED15)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RN5 / MED15_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 15
Gene Name Name: MED15
Synonyms:ARC105,CTG7A,PCQAP,TIG1,TNRC7;
Organism Homo sapiens (Human)

PRO ID PR:Q96RN5
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 15 (human)
Definition A mediator of RNA polymerase II transcription subunit 15 that is encoded in the genome of human.
Short Label hMED15
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RN5 (MED15) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 34725712, 30059200, 35254053, 35132862, 31492838, 35289036, 28657654
K18 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
T404 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...30379171, 34725712, 35132862, 30059200, 34019948, 31492838, 35289036, 35254053, 28657654
T405 O-Glycosylation GlyGen 33214551, 32938750, 35138101, ...30379171, 34725712, 34019948, 30059200, 35132862, 31492838, 35289036, 35254053, 28657654
S408 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...30379171, 34725712, 35132862, 30059200, 34019948, 31492838, 35289036, 35254053, 28657654
S412 O-Glycosylation GlyGen 34846842
S413 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 34725712, 30059200, 35254053, 35132862, 31492838, 35289036, 28657654
S414 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 34725712, 30059200, 35254053, 35132862, 31492838, 35289036, 28657654
S505 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
Y532 Phosphorylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
K578 Acetylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
T584 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 34725712, 30059200, 35254053, 35132862, 31492838, 35289036, 28657654
T603 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T612 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T603 Phosphorylation HPRD 19413330, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T563 Phosphorylation HPRD 19413330, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 F4 Biomuta DOID:4159 / skin cancer [ cosmic ]
S35 I35 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T404 P404 Biomuta DOID:1324 / lung cancer [ cosmic ]
S414 C414 Biomuta [ cosmic ]
S520 N520 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K535 Q535 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K578 T578 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S673 R673 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]