iPTMnet Report for Q96RL1 (UIMC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RL1 / UIMC1_HUMAN
Protein Name BRCA1-A complex subunit RAP80
Gene Name Name: UIMC1
Synonyms:RAP80,RXRIP110;
Organism Homo sapiens (Human)

PRO ID PR:Q96RL1
DAG View
PRO Name BRCA1-A complex subunit RAP80 (human)
Definition A BRCA1-A complex subunit RAP80 that is encoded in the genome of human.
Short Label hUIMC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RL1 (UIMC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Sumoylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K20 Sumoylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus   UniProt 23186163
K31 Sumoylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S44 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 26719330, 18669648, ...19690332, 20068231
S44 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26719330
S46 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231, ...26719330
S46 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26719330
K59 Ubiquitination PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K90 Sumoylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
R97 Methylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17525341, 23186163, 29396516, ...17525342
K112 Ubiquitination PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
S140 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 23186163, 17525340, ...29396516
S142 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
K166 Sumoylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S205 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 18519686, 29396516, 17621610
S205 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus 18519686, 17621610
S205 Phosphorylation Q13535 (ATR) PhosphoSitePlus 18519686
K215 Ubiquitination PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
R239 Methylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
K245 Methylation PhosphoSitePlus
K245 Sumoylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K308 Sumoylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
K382 Sumoylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
S402 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 29396516, 17621610, ...17525340
S402 Phosphorylation Q13315 (ATM) neXtProt 17621610
S415 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S419 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 29396516, 17525340
S421 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S463 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S466 Phosphorylation PhosphoSitePlus   UniProt 23186163
K480 Sumoylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K485 Sumoylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
K544 Sumoylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
K559 Sumoylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
K562 Sumoylation PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K587 Sumoylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
S597 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S602 Phosphorylation PhosphoSitePlus
K607 Sumoylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
S627 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21851590, 23186163
S627 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S632 Phosphorylation PhosphoSitePlus
K635 Sumoylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
S653 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935
S662 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
S677 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 15302935, ...18669648, 23264621, 20068231
S677 Phosphorylation P06493 (CDK1) PhosphoSitePlus 23264621
K680 Acetylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
K696 Acetylation PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
T700 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S46 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S101 Phosphorylation HPRD 19651622, 20068231
S140 Phosphorylation HPRD 17525332
S380 Phosphorylation HPRD 20068231
S383 Phosphorylation HPRD 20068231
S402 Phosphorylation HPRD 17525332
S415 Phosphorylation HPRD 17525332
S419 Phosphorylation HPRD 17525332
S463 Phosphorylation HPRD 18669648, 20068231
S597 Phosphorylation HPRD 15302935
S627 Phosphorylation HPRD 18669648
S653 Phosphorylation HPRD 19664994, 19664995, 18452278, ...17322306, 18669648, 20068231
S677 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S26 T26 Biomuta DOID:1324 / lung cancer [ cosmic ]
S27 Y27 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S44 F44 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K59 Q59 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T136 A136 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S140 F140 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S140 Y140 Biomuta DOID:4159 / skin cancer [ cosmic ]
S198 T198 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S198 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K215 N215 Biomuta DOID:363 / uterine cancer [ icgc ]
K305 R305 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K318 T318 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K372 E372 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S383 R383 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S402 F402 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S415 F415 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S463 A463 Biomuta DOID:10283 / prostate cancer [ icgc ]
S498 A498 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S498 T498 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K642 N642 Biomuta DOID:263 / kidney cancer [ cosmic ]
S662 N662 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S668 F668 Biomuta [ cosmic ]