Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RK0 / CIC_HUMAN
Protein Name Protein capicua homolog
Gene Name Name: CIC
Synonyms:KIAA0306;
Organism Homo sapiens (Human)

PRO ID PR:Q96RK0
DAG View
PRO Name protein capicua homolog (human)
Definition A protein capicua that is encoded in the genome of human.
Short Label hCIC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RK0 (CIC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 O-Glycosylation GlyGen 23301498, 27655845, 30397120, ...30059200, 21740066, 20305658, 32119511, 28657654, 29237092
R30 Methylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S142 Phosphorylation HPRD   PhosphoSitePlus 18452278
T144 Phosphorylation PhosphoSitePlus
S146 Phosphorylation HPRD   PhosphoSitePlus 18452278
T171 Phosphorylation HPRD   PhosphoSitePlus 19651622
S173 Phosphorylation Q15418 (RPS6KA1) , P51812 (RPS6KA3) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 18767875, 21087211, ...19651622, 18669648, 30737375, 24275569, 20068231
S175 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S211 Phosphorylation HPRD   PhosphoSitePlus 20068231
S231 Phosphorylation PhosphoSitePlus
S277 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S278 Phosphorylation HPRD   PhosphoSitePlus 17081983
S279 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231
S285 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S299 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S301 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
T303 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T305 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus   UniProt 24275569
S370 Phosphorylation PhosphoSitePlus
S431 Phosphorylation HPRD   PhosphoSitePlus 19651622
T435 Phosphorylation PhosphoSitePlus
S436 Phosphorylation HPRD   PhosphoSitePlus 19651622
T472 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S496 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T556 Phosphorylation PhosphoSitePlus
R572 Methylation PhosphoSitePlus
T583 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18847512
S585 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K586 Methylation PhosphoSitePlus
R599 Methylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
S665 O-Glycosylation GlyGen 23301498, 27655845, 30397120, ...30059200, 21740066, 20305658, 32119511, 28657654, 29237092
K689 Acetylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus   UniProt 24275569
S721 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S726 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S734 O-Glycosylation GlyGen 23301498, 27655845, 30397120, ...30059200, 21740066, 20305658, 32119511, 28657654, 29237092
S734 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus   UniProt 23186163
R863 Methylation PhosphoSitePlus   UniProt 24129315
S894 Phosphorylation PhosphoSitePlus
S902 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 20068231
S904 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 15345747
S914 Phosphorylation HPRD   PhosphoSitePlus 20068231
R934 Methylation PhosphoSitePlus
S946 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
T1002 O-Glycosylation GlyGen 23301498, 27655845, 30397120, ...30059200, 21740066, 20305658, 32119511, 28657654, 29237092
S1150 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
T1228 Phosphorylation PhosphoSitePlus
S1245 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T1291 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1306 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
T1318 Phosphorylation PhosphoSitePlus
K1329 Acetylation PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
S1351 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1373 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18452278, 19651622, 18669648, 19690332, 20068231
T1375 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983, ...20068231
S1378 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231, 18220336
T1381 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S1382 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 15302935, ...18452278, 19651622, 18669648, 19690332, 20068231
S1389 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   UniProt 23186163, 21087211
S1397 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18452278, ...24275569, 19690332
T1398 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 17081983, 24275569
S1402 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
T1408 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S1409 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 15302935, 21087211, ...18452278, 24275569, 19690332
S1418 Phosphorylation PhosphoSitePlus
S1419 Phosphorylation PhosphoSitePlus
S1422 Phosphorylation PhosphoSitePlus
T1426 Phosphorylation PhosphoSitePlus
S1429 Phosphorylation PhosphoSitePlus
S1462 Phosphorylation HPRD 17081983
S1595 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32169577, 24275569


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96RK0 (CIC) S173 Q8NG27 (PJA1) decreased_association eFIP 30737375


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R30 H30 Biomuta DOID:1909 / melanoma [ cosmic ]
R30 G30 Biomuta DOID:363 / uterine cancer [ tcga ]
S211 R211 Biomuta DOID:3070 / malignant glioma [ cosmic ]
S231 N231 Biomuta DOID:3070 / malignant glioma [ cosmic ]
S231 I231 Biomuta DOID:3070 / malignant glioma [ tcga ]
S231 G231 Biomuta DOID:3070 / malignant glioma [ tcga ]
S277 Y277 Biomuta DOID:363 / uterine cancer [ tcga ]
S278 N278 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ]
S301 P301 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S301 L301 Biomuta DOID:3070 / malignant glioma [ tcga ]
T303 M303 Biomuta DOID:1909 / melanoma [ cosmic ]
S335 F335 Biomuta DOID:1909 / melanoma [ tcga ]
S349 L349 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S431 I431 Biomuta DOID:3571 / liver cancer [ icgc ]
S431 N431 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T435 M435 Biomuta DOID:363 / uterine cancer [ icgc ]
R572 Q572 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ]
R572 W572 Biomuta DOID:363 / uterine cancer [ tcga ]
R599 Q599 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S665 Y665 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S726 R726 Biomuta DOID:3070 / malignant glioma [ cosmic ]
S730 W730 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S734 L734 Biomuta DOID:3571 / liver cancer [ icgc ]
S739 * Biomuta DOID:4362 / cervical cancer [ tcga ]
R863 L863 Biomuta DOID:3571 / liver cancer [ icgc ]
R863 C863 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S902 P902 Biomuta DOID:1115 / sarcoma [ tcga ]
R934 W934 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R934 Q934 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R934 G934 Biomuta DOID:4159 / skin cancer [ icgc ]
S1294 R1294 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1378 P1378 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1378 F1378 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S1389 F1389 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
T1398 M1398 Biomuta DOID:363 / uterine cancer [ tcga ]
S1409 L1409 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S1429 I1429 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1595 P1595 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
S1595 F1595 Biomuta DOID:3070 / malignant glioma [ cosmic ]