iPTMnet Report for Q96RK0 (CIC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RK0 / CIC_HUMAN
Protein Name Protein capicua homolog
Gene Name Name: CIC
Synonyms:KIAA0306;
Organism Homo sapiens (Human)

PRO ID PR:Q96RK0
DAG View
PRO Name protein capicua homolog (human)
Definition A protein capicua that is encoded in the genome of human.
Short Label hCIC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RK0 (CIC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...32938750, 35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S16 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
R30 Methylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S142 Phosphorylation HPRD   PhosphoSitePlus 18452278
T144 Phosphorylation PhosphoSitePlus
S146 Phosphorylation HPRD   PhosphoSitePlus 18452278
T171 Phosphorylation HPRD   PhosphoSitePlus 19651622
S173 Phosphorylation Q15418 (RPS6KA1) , P51812 (RPS6KA3) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20068231, 23186163, 18767875, ...21087211, 19651622, 18669648, 30737375, 24275569, 33103082
S175 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S211 Phosphorylation HPRD   PhosphoSitePlus 20068231
S231 Phosphorylation PhosphoSitePlus
S277 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S278 Phosphorylation HPRD   PhosphoSitePlus 17081983
S279 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231
S285 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S299 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S301 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 20068231, 33103082, 18452278
T303 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T305 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus   UniProt 24275569
S370 Phosphorylation PhosphoSitePlus
S431 Phosphorylation HPRD   PhosphoSitePlus 19651622
T435 Phosphorylation PhosphoSitePlus
S436 Phosphorylation HPRD   PhosphoSitePlus 19651622
T472 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S496 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S530 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S534 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...32938750, 35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S535 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S541 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S542 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S543 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T556 Phosphorylation PhosphoSitePlus
S566 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...34725712, 35138101, 34846842, 32574038, 30397120, 35132862, 21740066, 30059200, 34019948, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T567 O-Glycosylation GlyGen 32574038
R572 Methylation PhosphoSitePlus
T583 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T583 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18847512
S585 O-Glycosylation GlyGen 32574038
S585 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K586 Methylation PhosphoSitePlus
R599 Methylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
S649 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S665 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
K689 Acetylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus   UniProt 24275569
S721 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S726 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S734 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S734 Phosphorylation PhosphoSitePlus
T738 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S739 Phosphorylation PhosphoSitePlus   UniProt 23186163
T752 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T831 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
R863 Methylation PhosphoSitePlus   UniProt 24129315
T880 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S891 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S894 Phosphorylation PhosphoSitePlus
S902 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 20068231
S904 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 15345747
S914 Phosphorylation HPRD   PhosphoSitePlus 20068231
R934 Methylation PhosphoSitePlus
S946 Phosphorylation PhosphoSitePlus
T967 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S972 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...32938750, 35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T973 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S975 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S982 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S982 Phosphorylation PhosphoSitePlus
T985 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S991 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S1000 O-Glycosylation GlyGen 32574038
S1001 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T1002 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T1143 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
T1149 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S1150 Phosphorylation PhosphoSitePlus
S1154 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...35138101, 30397120, 32574038, 34725712, 34019948, 21740066, 30059200, 35132862, 31492838, 20305658, 32119511, 35289036, 35254053, 28657654, 29237092
S1173 Phosphorylation PhosphoSitePlus
T1228 Phosphorylation PhosphoSitePlus
S1245 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T1291 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1306 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
T1318 Phosphorylation PhosphoSitePlus
K1329 Acetylation PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
S1351 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1373 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18452278, 19651622, 18669648, 19690332, 20068231
T1375 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983, ...20068231
S1378 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231, 18220336
T1381 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S1382 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 15302935, ...18452278, 19651622, 18669648, 19690332, 20068231
S1389 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   PhosphoSitePlus   UniProt 23186163, 21087211
S1397 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18452278, ...24275569, 19690332
T1398 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 17081983, 24275569
S1402 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
T1408 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S1409 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 15302935, 21087211, ...18452278, 24275569, 19690332
S1418 Phosphorylation PhosphoSitePlus
S1419 Phosphorylation PhosphoSitePlus
S1422 Phosphorylation PhosphoSitePlus
T1426 Phosphorylation PhosphoSitePlus
S1429 Phosphorylation PhosphoSitePlus
S1462 Phosphorylation HPRD 17081983
S1595 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24275569, 32169577


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96RK0 (CIC) S173 Q8NG27 (PJA1) decreased_association eFIP 30737375


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R30 H30 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R30 G30 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S173 F173 Biomuta DOID:4159 / skin cancer [ cosmic ]
S211 R211 Biomuta DOID:1319 / brain cancer [ cosmic ]
S231 N231 Biomuta DOID:1319 / brain cancer [ cosmic ]
S231 I231 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S231 G231 Biomuta DOID:1319 / brain cancer [ cosmic, icgc, tcga ]
S277 Y277 Biomuta DOID:363 / uterine cancer [ icgc ]
S278 N278 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T295 M295 Biomuta DOID:3565 / meningioma [ cosmic ]
S301 P301 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S301 L301 Biomuta DOID:1319 / brain cancer [ cosmic, icgc, tcga ]
T303 K303 Biomuta DOID:4159 / skin cancer [ cosmic ]
T303 M303 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S335 F335 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S349 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S356 F356 Biomuta DOID:4159 / skin cancer [ cosmic ]
S431 N431 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T435 M435 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S474 R474 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S530 F530 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S535 F535 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S541 F541 Biomuta DOID:4159 / skin cancer [ cosmic ]
S543 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S543 L543 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R572 Q572 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R572 W572 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K586 * Biomuta DOID:1319 / brain cancer [ cosmic ]
R599 W599 Biomuta DOID:263 / kidney cancer [ cosmic ]
S665 Y665 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K689 T689 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S721 C721 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S726 R726 Biomuta DOID:1319 / brain cancer [ cosmic ]
S730 W730 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S734 L734 Biomuta DOID:4159 / skin cancer [ cosmic ]
S739 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
T831 M831 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
R863 C863 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S891 P891 Biomuta DOID:363 / uterine cancer [ icgc ]
S894 C894 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S902 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S904 C904 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S914 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S914 A914 Biomuta DOID:4159 / skin cancer [ cosmic ]
R934 W934 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S946 I946 Biomuta DOID:4159 / skin cancer [ cosmic ]
S972 T972 Biomuta DOID:4159 / skin cancer [ cosmic ]
T973 I973 Biomuta DOID:4159 / skin cancer [ cosmic ]
S991 C991 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1001 F1001 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1002 I1002 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1228 I1228 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1294 R1294 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1344 F1344 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1375 I1375 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1378 P1378 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1378 F1378 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1382 L1382 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1382 A1382 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1382 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S1389 F1389 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1397 T1397 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1398 M1398 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1408 I1408 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1409 L1409 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1418 C1418 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1429 I1429 Biomuta DOID:1319 / brain cancer [ icgc ]
S1462 A1462 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1595 F1595 Biomuta DOID:1319 / brain cancer [ cosmic ]