iPTMnet Report for Q96RG2 (PASK)
Protein Information
| UniProt AC / UniProt ID | Q96RG2 / PASK_HUMAN |
| Protein Name | PAS domain-containing serine/threonine-protein kinase |
| Gene Name | Name: PASK Synonyms:KIAA0135; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q96RG2 |
| PRO Name | PAS domain-containing serine/threonine-protein kinase (human) |
| Definition | A PAS domain-containing serine/threonine-protein kinase that is encoded in the genome of human. |
| Short Label | hPASK |
| Category | organism-gene |
Q96RG2 (PASK) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S40 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S42 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S60 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C83 | Methylation | score1 | IEDB | 31844290 | ||
| S104 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S109 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S116 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648, 15302935 | ||
| K132 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K218 | Acetylation | score1 | PhosphoSitePlus | |||
| T307 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 22065581 | ||
| K314 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K316 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S333 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| Y389 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S390 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S524 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S533 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| K570 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S579 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S582 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K594 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T640 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T642 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C660 | Methylation | score1 | IEDB | 31844290 | ||
| S667 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S670 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S843 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T874 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K930 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S939 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S949 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S953 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T954 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S956 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K981 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y999 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1000 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1001 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1003 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1034 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1045 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1057 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1122 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1149 | Phosphorylation | Q96RG2 (PASK) | score2 | neXtProt | 11459942 | |
| T1161 | Phosphorylation | Q96RG2 (PASK) | score3 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 11459942 | |
| T1165 | Phosphorylation | Q96RG2 (PASK) | score3 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 11459942 | |
| K1270 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1273 | Phosphorylation | Q96RG2 (PASK) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 18669648, 11459942 | |
| S1277 | Phosphorylation | Q96RG2 (PASK) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 18669648, 11459942 | |
| S1280 | Phosphorylation | Q96RG2 (PASK) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 18669648, 11459942 | |
| S1287 | Phosphorylation | Q96RG2 (PASK) | score2 | neXtProt | 11459942 | |
| S1289 | Phosphorylation | Q96RG2 (PASK) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 18669648, 11459942 | |
| T1322 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1323 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S116 | Phosphorylation | score0 | HPRD | 18669648, 15302935 | ||
| S333 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S524 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S533 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S949 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S953 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S956 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S1057 | Phosphorylation | score0 | HPRD | 18767875 | ||
| T1161 | Phosphorylation | Q96RG2 (PASK) | score1 | HPRD | 11459942 | |
| T1165 | Phosphorylation | Q96RG2 (PASK) | score1 | HPRD | 11459942 | |
| S1273 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S1277 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S1280 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S1289 | Phosphorylation | score0 | HPRD | 18669648 |
Q96RG2 (PASK) as PTM Enzyme
| Substrate | Site | Score | Source | PMID | |
|---|---|---|---|---|---|
| P13807 (GYS1) | S641 | score2 | neXtProt | 16275910 | |
| P52945 (PDX1) | T151 | score2 | neXtProt | 17052199 | |
| P62753 (RPS6) | S235 | score2 | neXtProt | 21418524 | |
| P62753 (RPS6) | S236 | score2 | neXtProt | 21418524 | |
| P68104 (EEF1A1) | T432 | score3 | neXtProt PhosphoSitePlus | 17595531 | |
| Q96RG2 (PASK) | S1149 | score2 | neXtProt | 11459942 | |
| Q96RG2 (PASK) | T1161 | score3 | HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt | 11459942 | |
| Q96RG2 (PASK) | T1165 | score3 | HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt | 11459942 | |
| Q96RG2 (PASK) | S1273 | score2 | neXtProt | 11459942 | |
| Q96RG2 (PASK) | S1277 | score2 | neXtProt | 11459942 | |
| Q96RG2 (PASK) | S1280 | score2 | neXtProt | 11459942 | |
| Q96RG2 (PASK) | S1287 | score2 | neXtProt | 11459942 | |
| Q96RG2 (PASK) | S1289 | score2 | neXtProt | 11459942 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S40 | L40 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S42 | F42 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S55 | C55 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| C83 | Y83 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S106 | P106 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T307 | I307 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S524 | R524 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T642 | N642 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| S956 | F956 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S956 | C956 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| Y999 | H999 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K1045 | N1045 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| K1122 | N1122 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S1149 | L1149 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T1161 | N1161 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| S1277 | F1277 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
DAG View