iPTMnet Report for Q96RD7 (PANX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96RD7 / PANX1_HUMAN
Protein Name Pannexin-1
Gene Name Name: PANX1
Synonyms:MRS1;ORFNames:UNQ2529/PRO6028;
Organism Homo sapiens (Human)

PRO ID PR:Q96RD7
DAG View
PRO Name pannexin-1 (human)
Definition A pannexin-1 that is encoded in the genome of human.
Short Label hPANX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96RD7 (PANX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus   RLIMS-P 33405952
S182 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K203 Acetylation PhosphoSitePlus
K204 Acetylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
N255 N-Glycosylation GlyGen   UniProt 17715132, 24190977, 30918116
S257 O-Glycosylation GlyGen 35289036
K307 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y150 C150 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y150 F150 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K203 N203 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K307 R307 Biomuta DOID:1324 / lung cancer [ cosmic ]
K343 N343 Biomuta DOID:363 / uterine cancer [ icgc ]