Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96R06 / SPAG5_HUMAN
Protein Name Sperm-associated antigen 5
Gene Name Name: SPAG5
Organism Homo sapiens (Human)

PRO ID PR:Q96R06
DAG View
PRO Name sperm-associated antigen 5 (human)
Definition A sperm-associated antigen 5 that is encoded in the genome of human.
Short Label hSPAG5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96R06 (SPAG5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 20068231
S14 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 20068231
T17 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
T37 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S39 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S43 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 19691289, ...22067460, 18669648
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S48 Phosphorylation PhosphoSitePlus
T50 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K55 Ubiquitination PhosphoSitePlus
S62 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 16565220, 22067460, ...18669648, 20068231
S65 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 20068231
S66 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231, ...16565220
K74 Ubiquitination PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
S79 Phosphorylation HPRD   PhosphoSitePlus 19691289
S86 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S109 Phosphorylation HPRD   PhosphoSitePlus 18691976
T111 Phosphorylation P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 18055457, 16565220
K113 Ubiquitination PhosphoSitePlus
S115 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 19691289, 25009111
Y125 Phosphorylation PhosphoSitePlus
S135 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 18691976, 27325694, 16565220, ...22067460, 18669648, 20068231
T151 Phosphorylation PhosphoSitePlus
S157 Phosphorylation HPRD   PhosphoSitePlus 19007248, 20068231, 19691289
S159 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19691289, ...20068231
K191 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S217 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S220 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S249 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P 27325694, 18691976, 16565220, ...22067460, 20068231
S334 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20068231, 16565220
T336 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S338 Phosphorylation HPRD   PhosphoSitePlus 20068231
S341 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 20068231, 18691976, ...16565220
T352 Phosphorylation HPRD 20068231
S353 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19691289, ...16565220, 22067460, 19007248, 20068231
S362 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19007248, 19691289, 22067460, ...16565220, 20068231
S364 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16565220
S367 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
T377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20068231, 16565220
T381 Phosphorylation PhosphoSitePlus
S383 Phosphorylation HPRD 20068231
T386 Phosphorylation HPRD 20068231
T389 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20068231, 16565220
K396 Ubiquitination PhosphoSitePlus
S397 Phosphorylation HPRD 18691976, 20068231, 16565220
T398 Phosphorylation HPRD 16565220
T400 Phosphorylation PhosphoSitePlus
S401 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 17525332, 19691289, ...16565220, 18669648, 19007248, 20068231
T403 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19007248, 19691289
K409 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
K794 Ubiquitination PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
K842 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
T937 Phosphorylation P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18055457, 16565220
S944 Phosphorylation PhosphoSitePlus
K946 Ubiquitination PhosphoSitePlus
T950 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
S974 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor   UniProt 18055457
T978 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor   UniProt 18055457
K1001 Ubiquitination PhosphoSitePlus
K1021 Ubiquitination PhosphoSitePlus
K1023 Acetylation PhosphoSitePlus
K1023 Ubiquitination PhosphoSitePlus
K1029 Acetylation PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
K1042 Ubiquitination PhosphoSitePlus
K1054 Ubiquitination PhosphoSitePlus
K1061 Ubiquitination PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
K1121 Ubiquitination PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
K1160 Ubiquitination PhosphoSitePlus
K1170 Ubiquitination PhosphoSitePlus
T1171 Phosphorylation PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
K1183 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S48 L48 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S86 F86 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y125 F125 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S197 C197 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S353 F353 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S353 Y353 Biomuta DOID:3571 / liver cancer [ icgc ]
S364 F364 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S367 L367 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T376 N376 Biomuta DOID:363 / uterine cancer [ tcga ]
T398 K398 Biomuta DOID:3571 / liver cancer [ icgc ]
S401 C401 Biomuta DOID:184 / bone cancer [ icgc ]
K483 T483 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc, tcga ]
S835 C835 Biomuta DOID:1324 / lung cancer [ cosmic ]
T950 I950 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K1001 * Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K1029 * Biomuta DOID:1324 / lung cancer [ tcga ]