iPTMnet Report for Q96QB1 (DLC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96QB1 / RHG07_HUMAN
Protein Name Rho GTPase-activating protein 7
Gene Name Name: DLC1
Synonyms:ARHGAP7,KIAA1723,STARD12;
Organism Homo sapiens (Human)

PRO ID PR:Q96QB1
DAG View
PRO Name Rho GTPase-activating protein 7 (human)
Definition A Rho GTPase-activating protein 7 that is encoded in the genome of human.
Short Label hDLC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96QB1 (DLC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S354 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
K513 Sumoylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus   UniProt 24275569
S526 Phosphorylation PhosphoSitePlus   UniProt 24275569
S535 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S548 O-Glycosylation GlyGen 30379171
S548 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
T738 Phosphorylation PhosphoSitePlus
T740 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
T755 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus   UniProt 24275569
S764 Phosphorylation PhosphoSitePlus
S766 Phosphorylation neXtProt   PhosphoSitePlus 16338927
S766 Phosphorylation P31749 (AKT1) neXtProt 16338927
T840 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
S928 Phosphorylation PhosphoSitePlus
S946 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
S991 Phosphorylation PhosphoSitePlus
T993 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
K1051 Ubiquitination PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
T1238 Phosphorylation IEDB   PhosphoSitePlus 27869121
S1244 Phosphorylation neXtProt   PhosphoSitePlus   Signor 21087603
S1244 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   Signor 21087603
S1355 Phosphorylation PhosphoSitePlus
T1435 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S327 Phosphorylation HPRD 16338927
S327 Phosphorylation P31749 (AKT1) HPRD 16338927
S329 Phosphorylation HPRD 16338927
S329 Phosphorylation P31749 (AKT1) HPRD 16338927
S549 Phosphorylation HPRD 19664995
S567 Phosphorylation HPRD 16338927
S567 Phosphorylation P31749 (AKT1) HPRD 16338927
Site PTM Type PTM Enzyme Score Source PMID
S764 Phosphorylation HPRD 16338927
S764 Phosphorylation P31749 (AKT1) HPRD 16338927
S766 Phosphorylation HPRD 16338927
S766 Phosphorylation P31749 (AKT1) HPRD 16338927
S986 Phosphorylation HPRD 19664995
S1004 Phosphorylation HPRD 16338927
S1004 Phosphorylation P31749 (AKT1) HPRD 16338927
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35579 (MYH9) S1943 Q96QB1 (DLC1) unknown eFIP 26977077
Phosphorylation P60484 (PTEN) T319 Q96QB1 (DLC1) unknown eFIP 26166433


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036641 (hBCL2L11/iso:2/Phos:1) decreased Interaction PR:Q96QB1 (hDLC1) PRO 12591950
PR:000044746 (hBCL2L11/iso:2/UnMod) Interaction PR:Q96QB1 (hDLC1) PRO 12591950


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S327 R327 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S329 N329 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S354 Y354 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K513 E513 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S577 R577 Biomuta DOID:3571 / liver cancer [ cosmic ]
S652 G652 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K707 N707 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T738 M738 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T738 S738 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S747 L747 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ]
T755 M755 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S757 N757 Biomuta DOID:3571 / liver cancer [ cosmic ]
S764 R764 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S766 N766 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T840 M840 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S859 G859 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S995 F995 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1055 G1055 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S1209 N1209 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1244 F1244 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1355 F1355 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]